https://www.mdlinx.com/internal-medicine/medical-news-article/2017/03/30/cimt-cholesterol-insulin-resistance-body-fat/7108753/?
Vascular Health and Risk Management
Fernstrom M, et al.
The objectives of the study
portrayed in this paper were to evaluate selected cardiometabolic
biomarkers, carotid intima–media thickness (cIMT) as a marker of
subclinical atherosclerosis, and lifestyle–associated indicators (food
habits, handgrip strength, and oxygen uptake, VO2 max);
examine the relationship between cIMT and lifestyle factors; and
recognize subjects at risk of cardiovascular disease (CVD) utilizing a
risk score and to compare the characteristics of subjects with and
without risk of CVD. High aerobic fitness is related to low CVD risk in
Swedish young adults. The high prevalence of young adults observed with
unfavorable levels of high–density lipoprotein cholesterol and
homeostasis model assessment of insulin resistance raises concerns about
future CVD risk.
Methods
- They collected blood samples in a fasting state, and food habits were reported through a questionnaire.
- In this study, cIMT was measured by ultrasound, and VO2 max was measured by ergometer bike test.
- The risk score was calculated according to Wildman.
Results
- In this study, they found cIMT (mean ± standard deviation) was 0.50±0.06 mm, and VO2 max values were 37.8±8.5 and 42.9±9.9 mL/kg/min, in women and men, respectively.
- No correlation was found between aerobic fitness expressed as VO2 max (mL/kg/min) and cIMT.
- By using Wildman’s definition, 12% of the subjects were classified as being at risk of CVD, and 15% had homeostasis model assessment of insulin resistance.
- An aggregate of 35% of women and 25% of men had lower high–density lipoprotein cholesterol than suggested.
- Food habits did not differ between those at risk and those not at risk.
- However, aerobic fitness measured as VO2 max (mL/kg/min) differed; 47% of the subjects at risk had low aerobic fitness compared to 23% of the nonrisk subjects (P<0.001).
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