- A population-based case-control study design with 1090 cases and 1154 controls was used to investigate the relationship of cocaine use and young-onset IS.
- Stroke cases were between the ages of 15 and 49 years.
- Logistic regression analysis was used to evaluate the association between cocaine use and IS with and without adjustment for potential confounders.
- Ever use of cocaine was not associated with stroke with 28% of cases and 26% of controls reporting ever use.
- In contrast, acute cocaine use in the previous 24 hours was strongly associated with increased risk of stroke (age-sex-race adjusted odds ratio, 6.4; 95% confidence interval, 2.2-18.6).
- Among acute users, the smoking route had an adjusted odds ratio of 7.9 (95% confidence interval, 1.8-35.0), whereas the inhalation route had an adjusted odds ratio of 3.5 (95% confidence interval, 0.7-16.9).
- After additional adjustment for current alcohol, smoking use, and hypertension, the odds ratio for acute cocaine use by any route was 5.7 (95% confidence interval, 1.7-19.7).
- Of the 26 patients with cocaine use within 24 hours of their stroke, 14 reported use within 6 hours of their event.