Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Wednesday, April 5, 2017

Brain Loss Slowed in Cognitive 'SuperAgers'

What protocol does your doctor have you on to make sure you are a 'Super Ager'? Not doing anything at all is a sign of extreme incompetence.
http://www.medpagetoday.com/neurology/dementia/64334
  • by
    Contributing Writer, MedPage Today
Cognitive "SuperAgers" – those over age 80 with above-average cognitive function – appear to be more resistant to age-related brain shrinkage than their cognitively average peers, researchers found.
While both groups had significant whole-brain cortical volume loss over 18 months, the annual percent change (APC) was significantly greater in the cognitively average elderly compared with SuperAgers (2.24% versus 1.06%, P=0.02), Amanda Cook, MA, of Northwestern University in Chicago, and colleagues reported in a research letter in the Journal of the American Medical Association.
"Our study found that while the brain cortex of both SuperAgers and their cognitively average peers showed shrinkage over 18 months, the rate of cortical brain atrophy in the adult controls was about double that of the SuperAgers," Cook told MedPage Today in an email.
While the effects of this observation are difficult to surmise, differences of this magnitude may have functional consequences, given that this rate of change is similar to that seen in previous studies between non-demented and demented adults over age 50 (e.g., range of APC differences of 0.5%-1.9%), the researchers said.
The study "demonstrates with a specific example that chronological age and biological age are not the same," Nir Barzilai, MD, director of the Albert Einstein College of Medicine Institute for Aging Research, who was not involved in the study, told MedPage Today in an email.
He added, however, that further study is needed to "uncover the biological and genetic explanations for such resiliency. This research reflects the cortical decline, but memory is stored in a different area and the study provides no information for that."
The study, which took place between April 2010 and May 2015, involved 36 individuals with intact daily functioning and stable cognitive status from the community. There were 24 SuperAgers (75% women) and 12 cognitively average elderly adults (42% women) who were similar in age (mean 83 years), levels of education (15 years), and intelligence.
SuperAgers had significantly higher category fluency at the first visit and episodic memory scores at both visits compared with cognitively average elderly adults, Cook said. There were no other significant differences between groups in demographic or neuropsychological measures, including estimated premorbid intelligence and between-visit interval.
Cook cautioned that the possibility that SuperAgers had bigger brains in midlife cannot be ruled out, "as we do not know what their brains looked like 30+ years ago." Previous research by her group showed that at a single time point, the cortex of the SuperAgers was bigger than that of their same-age peers with average memory ability for their age.
She said her study is "relevant in the context of our aging population. Modern medicine has extended the average human life span. However, increasing age is often accompanied by 'typical' cognitive decline or, in some cases ... dementia. SuperAgers suggest that age-related cognitive decline is not inevitable."
While biological health was not assessed in this study, research from the Northwestern University SuperAging Program has not yet found differences between SuperAgers and their cognitively average peers on aspects of physical health (such as diabetes and obesity) or various health behaviors (such as diet, exercise, smoking history, and drinking habits), Cook said.
"Anecdotally, we have SuperAgers who arrive for their study visits with walkers and wheelchairs so their superior cognitive abilities do not necessarily translate into superior physical health," she added.
Cook agreed with Barzilai that more research on this population is needed: "By studying what makes SuperAgers unique, we hope to undercover biological factors, such as the reduced cortical brain atrophy demonstrated here, that may contribute to the maintenance of memory ability in advanced age."
The study was funded by grants from the National Institutes of Health, including the Alzheimer's Disease Core Center, the National Institute on Aging, and the National Institute of Neurological Disorders and Stroke, as well as by a grant from the Davee Foundation.
The authors disclosed no financial conflicts of interest.

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