Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Friday, July 21, 2017

Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex

What about humans?  If the motor cortex is not needed for walking in mice then why is my walking still screwed up?  Of course my pre-motor cortex is mostly dead also, no idea how much white matter damage there is underlying those cortex areas. Because I never got any objective damage diagnosis I have no idea what needs fixing.
http://www.cell.com/neuron/fulltext/S0896-6273(17)30594-9
Publication stage: In Press Corrected Proof

Highlights

  • In mice, motor cortex is required for a trained forelimb task, but not walking
  • Motor cortex activates short-latency effector pathways only during the trained task
  • Distinct weighted sums of motor cortical firing patterns vary strongly in each task
  • This change could permit motor cortex to engage short-latency pathways differentially

Summary

Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor cortical activity together with electromyography in mice during two forelimb movements that differ in their requirement for cortical involvement. Rapid optogenetic silencing and electrical stimulation indicated that short-latency pathways linking motor cortex with spinal motor neurons are selectively activated during one behavior. Analysis of motor cortical activity revealed a dramatic change between behaviors in the coordination of firing patterns across neurons that could account for this differential influence. Thus, our results suggest that changes in motor cortical output patterns enable a behaviorally selective engagement of short-latency effector pathways. The model of motor cortical influence implied by our findings helps reconcile previous observations on the function of motor cortex.

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