Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Sunday, July 30, 2017

Monocyte depletion early after stroke promotes neurogenesis from endogenous neural stem cells in adult brain

This would seem to be very important for our 100% recovery. You better save up your money to hire researchers to accomplish this as a stroke protocol.


Depletion of circulating monocytes after stroke enhances striatal neurogenesis
Infiltrating monocytes compromise survival of newly generated neuroblasts
Depletion of circulating monocytes after stroke attenuates reactive gliosis
Infiltrating monocytes do not affect neurogenesis from grafted human NSPCs


Ischemic stroke, caused by middle cerebral artery occlusion, leads to long-lasting formation of new striatal neurons from neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) of adult rodents. Concomitantly with this neurogenic response, SVZ exhibits activation of resident microglia and infiltrating monocytes. Here we show that depletion of circulating monocytes, using the anti-CCR2 antibody MC-21 during the first week after stroke, enhances striatal neurogenesis at one week post-insult, most likely by increasing short-term survival of the newly formed neuroblasts in the SVZ and adjacent striatum. Blocking monocyte recruitment did not alter the volume of the ischemic lesion but gave rise to reduced astrocyte activation in SVZ and adjacent striatum, which could contribute to the improved neuroblast survival. A similar decrease of astrocyte activation was found in and around human induced pluripotent stem cell (iPSC)-derived NSPCs transplanted into striatum at one week after stroke in monocyte-depleted mice. However, there was no effect on neurogenesis in the graft as determined 8 weeks after implantation. Our findings demonstrate, for the first time, that a specific cellular component of the early inflammatory reaction in SVZ and adjacent striatum following stroke, i.e., infiltrating monocytes, compromises the short-term neurogenic response neurogenesis from endogenous NSPCs.


  • GFAP, glial fibrillary acidic protein;
  • iPSCs, induced pluripotent stem cells;
  • MCAO, middle cerebral artery occlusion;
  • MCP-1, monocyte chemoattractant protein-1;
  • MDMs, monocyte-derived macrophages;
  • NSPCs, neural stem/progenitor cells;
  • OB, olfactory bulb;
  • OPN, osteopontin;
  • SVZ, subventricular zone


  • Neurogenesis;
  • Monocyte depletion;
  • Reactive gliosis
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