In the 8 years since this earlier one came out has anything been done to get this into a stroke protocol? Does no one think about all the survivors needing this to help get recovered?
Ischemic postconditioning as a novel avenue to protect against brain injury after stroke Sept. 2009
Non-invasive remote ischemic postconditioning stimulates neurogenesis during the recovery phase after cerebral ischemia
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Abstract
Ischemic
postconditioning (IPostC) has been reported to have neuroprotection
against ischemic diseases, and one cycle of IPostC induces neurogenesis
when treated nearby. To expanding these effects, we explored the effects
of repetitively remote IPostC (NRIPostC) on neurogenesis in the
subgranular zone (SGZ) and subentricular zone (SVZ) during stroke
recovery. Animals underwent transient cerebral ischemia were treated
with vehicle or NRIPostC immediately after reperfusion. Neurological
severity scores, infarct size, neurogenesis, and protein expression
levels of nestin and GFAP were quantified at 3d, 7d, 14d, 21d and 28d
post-ischemia. Results showed that NRIPostC significantly reduced acute
infarction and improved neurological outcomes during the recovery phase.
Meanwhile, NRIPostC significantly increased the number of BrdU+/nestin+ cells in SGZ on day 14 and in the SVZ on days 3, 7 and 14 respectively, and the number of DCX+ cells from days 3 to 14. There were significant increments in the number of BrdU+/NeuN+ and BrdU+/GFAP+
cells in the SGZ and SVZ during the stroke recovery. The changing
tendency of the protein expression of nestin and GFAP in DG was
consistent with the result mentioned above. In conclusion, NRIPostC
reduced acute infarction and improved functional outcomes up to 28d, and
it induced neurogenesis both in the SGZ and SVZ.
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