Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,112 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Tuesday, October 31, 2017
Nitric Oxide Signaling in Neurodegeneration and Cell Death
In
this tribute to Solomon H. Snyder (Sol) we discuss the mechanisms by
which nitric oxide (NO) kills neurons. We provide a historical
perspective regarding the discovery that glutamate excitotoxicity is
mediated by NO. It also contains a discussion of the discovery that
neuronal nitric oxide synthase (nNOS) catalytic activity accounts for
NADPH diaphorase activity and its localization in the central nervous
system. NADPH diaphorase/nNOS neurons are unique in that they are
resistant to toxic effects of excess glutamate and that they are
resistant to neurodegeneration in a variety of neurodegenerative
diseases. NADPH diaphorase/nNOS neurons are resistant to neurotoxicity
and neurodegeneration through the overexpression of manganese superoxide
dismutase. The review also delves into the mechanisms by which NO kills
neurons including NO's activation of the glyceraldehyde-3-phosphate
dehydrogenase-dependent cell pathway. In addition, there is a review of
parthanatos in which NO combines with the superoxide anion (
) to form peroxynitrite (ONOO−)
that damages DNA and activates poly (ADP-ribose) (PAR) polymerase
(PARP). This ultimately leads to activation of the PARP-dependent
apoptosis-inducing factor-associated nuclease, the final executioner in
NO-dependent cell death. Finally, there is a discussion of potential
targets that are under development that target the mechanisms by which
NO kills neurons.
Keywords
NADPH diaphorase
Nitric oxide
Neuronal nitric oxide synthase
Parthanatos
Poly (ADP-ribose) polymerase
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