Effect of comprehensive rehabilitation training on prevention of post-stroke dementia: a randomized controlled trial

You will have to send your doctor after the protocol on this dementia prevention. You will need it.

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
3. A 20% chance in this research.   July 2013.

Effect of comprehensive rehabilitation training on prevention of post-stroke dementia: a randomized controlled trial

Yongbin Shi,1
, Zhanxing Zhang, 2
1
Department of Clinical Psychology, Hospital of Traditional Chinese and Western Medicine, Baoshan, Shanghai, China;
2
Department of Psychiatry, Mental Health Center, Baoshan, Shanghai, China
Received August 4
, 2016; Accepted September 22
, 2016; Epub May 15, 2017; Published May 30, 2017
Abstract:
To  evaluate  the  difference  in  the  prevention  of  cognitive  impairment  and  the  incidence  of  dementia  in  patients with initial stroke between comprehensive rehabilitation training (a combination of cognitive training, rehabilitation training  and  patient  education)  plus  medical  treatment  and  medical  treatment  alone.  A  total  of  200 patients  from  April  2013  to  April  2015  with  initial  onset  of  ischemic  stroke  were  included.  These  patients  were 
randomized into the experimental group (comprehensive rehabilitation training plus medical treatment) and control group (medical treatment alone) in a 1:1 ratio to receive treatment for 6 months and follow-up for 12 months. The proportion of patients with dementia, the changes from baseline of MMSE (Minimum Mental State Examination) and ADL (activities of daily living score) as well as the proportion of patients with anxiety and patient with depression were evaluated and compared between two groups. There was no significant difference in the proportion of patients with dementia between experimental group and control group at 3 months and 6 months. However, the proportion of patients with dementia in experimental group was significantly lower than control group at 12 months of follow-up
(7.70% vs. 19.20%, P=0.041). The changes from baseline of MMSE (1.67±0.34, 95% CI: 1.59-1.75 vs. 5.22±0.31, 95% CI: 5.15-5.29,P<0.001) and ADL (2.73±0.20, 95% CI: 2.69-2.77 vs. 3.45±0.27, 95% CI: 3.39-3.51, P<0.001) in experimental group were significantly decreased when compared to control group at 12th months. In addition, the proportion of patients with anxiety in the experimental group was significantly lower than control group (24.70% vs. 44.60%, P=0.007); whereas no significant difference was observed in the proportion of patients with depression between experimental group and control group (43.20% vs. 45.80%,
P=0.74). This study indicates that the comprehensive rehabilitation training reduces the incidence of post-stroke dementia as well as significantly prevents the cognitive function impairment, anxiety and improves activities of daily living in patients of stroke.