Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, June 4, 2019

P75-T Adaptation of the motor system is associated with neuroplasticity

I got absolutely nothing out of this. Did your doctor? 

P75-T Adaptation of the motor system is associated with neuroplasticity

Background

Repetition suppression (RS), i.e., adaption of neural excitability in response to a repeated stimulus, manifests as a decrement in the amplitude of the motor evoked potentials (MEPs) following repeated transcranial magnetic stimulation (TMS) of the motor cortex. RS is associated with abnormal adaptation to external stimuli and may be indicative of neuroplastic capacity.

Objective

To investigate the association between RS and experimentally induced plasticity.

Methods

Fourteen healthy subjects (7 males, aged 22–42 years) were studied with a RS paradigm, which was applied prior and following (0 min, 10 min, and 20 min) paired associative stimulation (PAS). The RS paradigm, consisting of twenty trains of four TMS pulses with an inter-stimulus interval (ISI) of 1 s and an inter-train interval (ITI) of 17 s, was applied to abductor pollicis brevis muscle ‘hotspot’. During PAS, median nerve stimulation was delivered 25 ms prior to TMS pulses given at 0.2 Hz for 15 min.

Results

A two-way repeated ANOVA identified 6 subjects with an interaction effect of RS and PAS (p < 0.05). Furthermore, the linear mixed model revealed a significant effect of PAS on RS by time in the responders ((F10min = 4.965, p10min = 0.033) and (F20min = 7.519, p20min = 0.010)). An independent samples t-test revealed that the resting motor threshold was significantly lower in responders than in non-responders (p = 0.05).

Conclusion

Our results demonstrate that RS is facilitated in subjects showing the interaction effect. This interaction might be mediated by the GABAergic inhibitory system during activation of the negative thalamo-cortical feedback loop due to the homeostatic plasticity.

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