Deans' stroke musings: Priming the Brain to Capitalize on Metaplasticity in Stroke Rehabilitation

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, October 15, 2019

Priming the Brain to Capitalize on Metaplasticity in Stroke Rehabilitation

You can have your doctor get this to see if it is useful. Assuming that your doctor does more than write E.T.(Evaluate and Treat) prescriptions

Priming the Brain to Capitalize on Metaplasticity in Stroke Rehabilitation

Jessica M. Cassidy, Bernadette T. Gillick, James R. Carey J.M. Cassidy,

PT, DPT, Doctoral Candidate , DPT Program in Physical Therapy and Graduate Program in Rehabilitation Science, University of Minnesota, 420 Delaware St SE, MMC 388, Minneapolis, MN 55455 (USA). Address all correspondence to Ms Cassidy at: krea0014@umn.edu. B.T. Gillick,

PT, PhD, Program in Physical Therapy and Graduate Program in Rehabilitation Science, University of Minnesota.

J.R. Carey,

PT, PhD, Program in Physical Therapy and Graduate Program in Rehabilitation Science, University of Minnesota. [Cassidy JM, Gillick BT, Carey JR. Priming the brain to capitalize on metaplasticity in stroke rehabilitation.
Phys Ther
. 2014;94:xxxÐxxx.]

2 © 2013 American Physical Therapy Association Published Ahead of Print: XXX Accepted: August 2, 2013 Submitted: January 27, 2013

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is emerging as a potentially valuable intervention to augment the effects of behavioral therapy for stroke. When used in conjunction with other therapies, rTMS embraces the concept of metaplasticity. Due to homeostatic mechanisms inherent to metaplasticity, interventions known in isolation to enhance excitability can interact when applied successively under certain timing conditions and produce enhanced or opposite effects. It will be shown that similar to Òmuscular wisdomÓ, with its self-protective mechanisms, there also appears to be synaptic wisdom in neural networks with homeostatic processes that prevent over- and under-excitability. These processes hold implications for both enhancing and suppressing the desired effects from behavioral therapy. The purpose of this paper is to relate the concept of metaplasticity, as derived from studies in healthy humans, to stroke rehabilitation and consider how it can be leveraged to maximize stroke outcomes.