Now YOU just need to insist that your incompetent doctors and stroke hospitals get human testing going. Or YOU get every leader in that stroke hospital fired starting with the board of directors.
I still prefer handing your doctor a pee cup and asking for stem cells in return. It has only been 8 years, where the fuck is your doctor's protocol on turning urine into stem cells?
Turning urine into brain cells could help fight Alzheimer’s, Parkinson’s
December 2012
Oops, I'm not playing by the polite rules of Dale Carnegie, 'How to Win Friends and Influence People'.
Politeness will never solve anything in stroke. Yes, I'm a bomb thrower and proud of it. Someday a stroke "leader" will ream me out for being truthful by making them look bad, I look forward to that day.
The latest here:
Repairing stroke-damaged rat brains
- Date:
- April 8, 2020
- Source:
- Lund University
- Summary:
- Researchers have succeeded in restoring mobility and sensation of touch in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into the rats' brains.
- Share:
FULL STORY
Researchers at Lund University in
Sweden have succeeded in restoring mobility and sensation of touch in
stroke-afflicted rats by reprogramming human skin cells to become nerve
cells, which were then transplanted into the rats' brains. The study has
now been published in the Proceedings of the National Academy of Sciences (PNAS).
"Six months after the transplantation, we could see how the new cells
had repaired the damage that a stroke had caused in the rats' brains,"
says Professor Zaal Kokaia, who together with senior professor Olle
Lindvall and researcher Sara Palma-Tortosa at the Division of Neurology
is behind the study.
Several previous studies from the Lund team and others have shown that it is possible to transplant nerve cells derived from human stem cells or from reprogrammed cells into brains of rats afflicted by stroke. However, it was not known whether the transplanted cells can form connections correctly in the rat brain in a way that restores normal movement and feeling.
The researchers have used human skin cells that have been reprogrammed in the laboratory to become nerve cells. They were then transplanted into the cerebral cortex of rats, in the part of the brain that is most often damaged after a stroke. Now the researchers will undertake further studies.
"We want to know more about how the transplanted cells affect the opposite hemisphere of the brain. We also want to take a closer look at how a transplant affects intellectual functions such as memory. In addition, we will study possible side effects. Safety is, of course, extremely important for cell transplantation if it is going to be used clinically in the future," says Zaal Kokaia.
Several previous studies from the Lund team and others have shown that it is possible to transplant nerve cells derived from human stem cells or from reprogrammed cells into brains of rats afflicted by stroke. However, it was not known whether the transplanted cells can form connections correctly in the rat brain in a way that restores normal movement and feeling.
"We have used tracking techniques, electron
microscopy and other methods, such as light to switch off activity in
the transplanted cells, as a way to show that they really have connected
correctly in the damaged nerve circuits. We have been able to see that
the fibres from the transplanted cells have grown to the other side of
the brain, the side where we did not transplant any cells, and created
connections. No previous study has shown this," says Zaal Kokaia, who,
even though he and colleague Olle Lindvall have studied the brain for
several decades, is surprised by the results.
"It is remarkable to find that it is actually possible to repair a
stroke-damaged brain and recreate nerve connections that have been lost.
The study kindles hope that in the future it could be possible to
replace dead nerve cells with new healthy nerve cells also in stroke
patients, even though there is a long way to go before achieving that,"
says Olle Lindvall.The researchers have used human skin cells that have been reprogrammed in the laboratory to become nerve cells. They were then transplanted into the cerebral cortex of rats, in the part of the brain that is most often damaged after a stroke. Now the researchers will undertake further studies.
"We want to know more about how the transplanted cells affect the opposite hemisphere of the brain. We also want to take a closer look at how a transplant affects intellectual functions such as memory. In addition, we will study possible side effects. Safety is, of course, extremely important for cell transplantation if it is going to be used clinically in the future," says Zaal Kokaia.
Story Source:
Materials provided by Lund University. Note: Content may be edited for style and length.
Materials provided by Lund University. Note: Content may be edited for style and length.
Journal Reference:
- Sara Palma-Tortosa, Daniel Tornero, Marita Grønning Hansen, Emanuela Monni, Mazin Hajy, Sopiko Kartsivadze, Sibel Aktay, Oleg Tsupykov, Malin Parmar, Karl Deisseroth, Galyna Skibo, Olle Lindvall, Zaal Kokaia. Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior. Proceedings of the National Academy of Sciences, 2020; 202000690 DOI: 10.1073/pnas.2000690117
Cite This Page:
Lund
University. "Repairing stroke-damaged rat brains." ScienceDaily.
ScienceDaily, 8 April 2020. www.sciencedaily.com/releases/2020/04/200408102150.htm.
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