By using the benign word 'neuroprotection' 100% of stroke survivors won't understand how important this is. But rewording it to 'Stopping the neuronal cascade of death by a Combination of the Biological Antioxidant (Eucalyptus Extract) and the Antihypertensive Drug Candesartan against Chronic Cerebral Ischemia in Rats' would perk up the ears considerably and get to asking their doctors what the fuck they are doing about stopping the neuronal cascade of death in the first week. And a few medical malpractice suits asking for $1000 a dead neuron might concentrate the stroke medical worlds mind. I lost 5.4 billion neurons that first week. 5.4 trillion dollars!
But your doctor should already be using Candesartan on you.
generic drug candesartan (brand name: ATACAND®) Blood Pressure Drug Helps Alzheimer's June 2018
This line from there is instructive:
The scientists found that candesartan prevented glutamate-induced neuronal death.
The latest here:
Study of Neuroprotection by a Combination of the Biological Antioxidant (Eucalyptus Extract) and the Antihypertensive Drug Candesartan against Chronic Cerebral Ischemia in Rats
by
1,2,†, 1,†, 3
, 4, 4,* and 2,3,*
, 4, 4,*
and 2,3,*
1
Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut P.O. Box 6573/14, Lebanon
2
Rammal Hassan Rammal Research Laboratory,
Physiotoxicity (PhyTox), Faculty of Sciences, Lebanese University,
Beirut P.O. Box 6573/14, Lebanon
3
Plateforme de recherche et d’analyse en sciences de l’environnement (EDST-PRASE), Beirut P.O. Box 6573/14, Lebanon
4
Aix Marseille University, CNRS, Centrale Marseille, iSm2, 13397 Marseille, France
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Raffaele Capasso
Molecules 2021, 26(4), 839; https://doi.org/10.3390/molecules26040839 (registering DOI)
Received: 5 December 2020 / Revised: 28 January 2021 / Accepted: 30 January 2021 / Published: 5 February 2021
Chronic cerebral ischemia with a notable long-term cessation of blood
supply to the brain tissues leads to sensorimotor defects and short- and
long-term memory problems. Neuroprotective agents are used in an
attempt to save ischemic neurons from necrosis and apoptosis, such as
the antioxidant agent Eucalyptus.
Numerous studies have demonstrated the involvement of the
renin-angiotensin system in the initiation and progression of
cardiovascular and neurodegenerative diseases. Candesartan is a drug
that acts as an angiotensin II receptor 1 blocker. We established a rat
model exhibiting sensorimotor and cognitive impairments due to chronic
cerebral ischemia induced by the ligation of the right common carotid
artery. Wistar male rats were randomly divided into five groups: Sham
group, Untreated Ligated group, Ischemic group treated with Eucalyptus (500 mg/kg), Ischemic group treated with Candesartan (0.5 mg/kg), and Ischemic group treated with a combination of Eucalyptus
and Candesartan. To evaluate the sensorimotor disorders, we performed
the beam balance test, the beam walking test, and the modified sticky
test. Moreover, the object recognition test and the Morris water maze
test were performed to assess the memory disorders of the rats. The
infarct rat brain regions were subsequently stained using the
triphenyltetrazolium chloride staining technique. The rats in the Sham
group had normal sensorimotor and cognitive functions without the
appearance of microscopic ischemic brain lesions. In parallel, the
untreated Ischemic group showed severe impaired neurological functions
with the presence of considerable brain infarctions. The treatment of
the Ischemic group with a combination of both Eucalyptus and Candesartan was more efficient in improving the sensorimotor and cognitive deficits (p < 0.001) than the treatment with Eucalyptus or Candesartan alone (p < 0.05), by the comparison to the non-treated Ischemic group. Our study shows that the combination of Eucalyptus and Candesartan could decrease ischemic brain injury and improve neurological outcomes.
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Keywords:
chronic cerebral ischemia; Candesartan; Eucalyptus; rats
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