This prediction doesn't get survivors recovered, does it? So useless research!
You're fired!
Abstract 374: Predictors of early intracerebral hemorrhage in patients with cerebral sinus venous thrombosis: Systematic review and meta‐analysis
Stroke: Vascular and Interventional Neurology
Abstract
Objectives
Patients
with cerebral venous thrombosis (CVT) may present with early
intracerebral hemorrhage (EICH). The objective of this study was to
identify predictors for EICH in CVT patients via a systematic review and
meta‐analysis of observational studies.
Methods
Literature
search on PubMed, EMBASE and Cochrane Library databases from inception
up to 1 February 2024 was conducted. Five studies with predictors of
EICH were included in qualitative synthesis and meta‐analysis.
Results
Pooled
analysis demonstrated a statistically significant association between
female gender and EICH (odd ratios (OR) = 1.51, 95% confidence interval
(CI) = 1.23‐1.85, p < 0.01). The ICH patients had higher likelihood
of seizures (OR = 3.07, 95% CI = 1.69‐5.58, p < 0.01), focal
neurological deficits (OR = 4.07, 95% CI = 2.57‐6.44, p < 0.01), and
decreased level of consciousness (OR=3.89, 95% CI = 2.53‐5.87, p <
0.01). Superior Sagittal Sinus thrombosis was associated with higher
likelihood of EICH (OR: 1.49, 95% CI 1.05‐2.13, P = 0.03). No
statistically significant association was demonstrated between presence
of EICH and pregnancy, presence of hematological diseases or
thrombophilia, or other site of venous thrombosis (deep venous system,
or multiple sinuses involvement). Furthermore, patients who exhibited
early EICH were notably less likely to attain a favorable functional
outcome (mRS 0‐2) (OR: 0.28; 95% CI 0.16‐0.49; p < 0.001).
Conclusion
This
meta‐analysis demonstrates that among CVT patients, female patients
with new onset seizures, focal neurological deficits and decreased level
of consciousness are more likely to present with EICH
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