Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, April 28, 2025

Amantadine continuation after hospital discharge for acute stroke requiring inpatient rehabilitation: a long-term follow-up study 1-5-25

 What did your hospital do with this from 13 years ago? NOTHING? Then they revel in their incompetence assuming that stroke survivors won't find out and don't care.  I bet absolutely fucking nothing has been done to get clinical research done and a stroke protocol written up.
  • amantadine (8 posts to February 2012)

    • Amantadine continuation after hospital discharge for acute stroke requiring inpatient rehabilitation: a long-term follow-up study 1-5-25

    Author links open overlay panel Haley R. Torr Pharm D 1Sara Penrod SLP-CCC 2, Jennifer Cote OTR/L 2, Sara E. Hanken PTMPT 2, Stephanie C. Chan MD 3, Riker MD 456Angela Leclerc MSPAPA-C 45, Teresa L. May DO 45, David B. Seder MD 4 >5 6 7, David J. Gagnon PharmD 1 67

    Abstract

    Objectives To describe the dosing strategy, safety, and effectiveness of amantadine in patients admitted to inpatient rehabilitation after stroke.
    Design Retrospective, single-center, cohort study
    90-bed, inpatient rehabilitation hospital
    Participants28 patients with amantadine started in a neuroICU after stroke and continued after transfer to rehabilitation; the median age was 67 years and 61% were male.

    Interventions

    Oral amantadine

    Main Outcome Measures

    Amantadine prescribing practices, adverse drug effects, and changes in recovery trajectory relative to dose changes.

    Results

    This cohort included 14 adult patients with intracerebral hemorrhage, 10 with subarachnoid hemorrhage, and 4 with acute ischemic stroke. The most common admitting amantadine dose was 100 mg twice daily. Inpatient rehabilitation lasted 27 (24-35) days, and amantadine was discontinued during rehabilitation in 6 patients (21%). Amantadine was prescribed to 22 patients (79%) at discharge from rehabilitation, most commonly 100 mg daily or twice daily, and was continued for 105 (39-510) days after admission to rehabilitation among the 17 patients with this data available. Twenty-one potential adverse events were identified among 16 (57%) patients, including confusion or delirium, sleeplessness, agitation, fatigue or lethargy, and spasticity; 8 of these (38%) occurred after reductions in amantadine dose.

    Conclusions

    Amantadine dosing was highly variable during inpatient rehabilitation, with trends for longer dosing after acute ischemic stroke and shorter for subarachnoid hemorrhage. Amantadine appeared well tolerated during and after inpatient rehabilitation, and most (22/28) patients were prescribed amantadine at discharge. Strategies to guide long-term use of amantadine following acute stroke require further prospective study.

    Keywords

    Amantadine
    Ischemic Stroke
    Subarachnoid Hemorrhage
    Cerebral Hemorrhage
    Rehabilitation
    Adverse Drug Effects
    Brain Injuries
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