Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, April 21, 2025

Low intensity gamma-frequency TMS safely modulates gamma oscillations in probable mild Alzheimer's dementia: a randomized 2x2 crossover pilot study

 Didn't your competent? doctor start creating protocols on this years ago? NO? So, you DON'T have a competent doctor? Why are you there? Now if we just had someone in stroke with two functioning neurons to rub together, we could easily get a protocol written on this and get survivors recovered! BUT WE HAVE NO ONE WITH BRAINS WORKING IN STROKE! With your risk of dementia, you might want this as a preventative.

gamma oscillations (14 posts to May 2021)

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018  

The latest here:

Low intensity gamma-frequency TMS safely modulates gamma oscillations in probable mild Alzheimer's dementia: a randomized 2x2 crossover pilot study

Alberto MimenzaAlberto Mimenza1Sara Gloria Aguilar-NavarroSara Gloria Aguilar-Navarro1Irvin Emmanuel Abarca-JiménezIrvin Emmanuel Abarca-Jiménez2Irina Vazquez-VillaseñorIrina Vazquez-Villaseñor3Diana Iris Luna-UmanzorDiana Iris Luna-Umanzor3Coralie DorardCoralie Dorard3Gabriel VillafuerteGabriel Villafuerte3*
  • 1Department of Geriatric Medicine & Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
  • 2Faculty of Medicine, National Autonomous University of Mexico, Mexico City, México, Mexico
  • 3Actipulse Neuroscience, Inc., Cambridge, Massachussetts, United States

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    Introduction: AD is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. While traditional treatments targeting beta-amyloid accumulation have shown limited success, there is a pressing need for novel therapeutic approaches. Recent studies have highlighted the role of disrupted gamma oscillations in AD pathology, leading to the exploration of gamma neuromodulation as a potential therapeutic strategy to modify disease progression in individuals with AD dementia. This pilot clinical trial aimed to investigate the electrophysiological effects of low intensity gamma transcranial magnetic stimulation (gTMS) on gamma oscillations in patients with a diagnosis of probable mild AD dementia. Methods: Employing a randomized, double-blind, sham-controlled, 2x2 crossover design, participants underwent a single session of both real low intensity gTMS and sham stimulation. EEG recordings and cognitive assessments were conducted before and after stimulation to assess changes in brain activity and their impact on episodic memory. Results: We observed statistically significant changes in EEG activity (n=14), indicating transient modulation of gamma oscillations immediately after low intensity gTMS. There was no significant improvement in cognition compared to baseline scores, but we evidenced a positive correlation between electrophysiological changes and cognitive outcome. Importantly, the intervention was well-tolerated, with no significant adverse effects reported. Discussion: Low intensity gTMS has shown the capability to induce significant changes in brain activity, particularly in gamma oscillations. These findings suggest that low intensity gTMS holds promise as a safe and non-invasive therapeutic approach, challenging the conventional belief that high intensity magnetic pulses are necessary for effective brain modulation. To corroborate these initial findings, further research with extended intervention durations and larger, well-defined cohorts of patients with mild AD dementia is essential. This will validate the potential benefits of low intensity gTMS on cognitive performance in this population.

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