Association Between Statin Use and Risk of Subarachnoid Hemorrhage: A Case-Control Study Using Large-Scale Claims Data

Ask your competent? doctor to explain why no protocol on statins exist! 

Better recovery with statins and this benefit.

But didn't your competent? doctor immediately prescribe statins to help in your recovery?

Or don't you have a functioning stroke doctor who incompetently missed this research from 2011?

1. Statins.

tested in rats from 2003

http://Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke  

Simvastatin Attenuates Stroke-induced Splenic Atrophy and Lung Susceptibility to Spontaneous Bacterial Infection in Mice

Or,

Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons 

October 2012

tested in humans, March, 2011

http://www.medwirenews.com/39/91658/Stroke/Acute_statin_therapy_improves_survival_after_ischemic_stroke.html

And now lost even to the Wayback Machine

So I think this below is the actual research;

Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke April 2011

The latest here:

Association Between Statin Use and Risk of Subarachnoid Hemorrhage: A Case-Control Study Using Large-Scale Claims Data

Hagiwara, RPhMaeda-Minami RPh, PhD https://orcid.org/0000-0003-1361-4514 ayako.maeda@rs.tus.ac.jpFumihiro Matano, MD, PhD https://orcid.org/0000-0002-0760-5024 s00-078@nms.ac.jp, Yohei Nounaka, MD https://orcid.org/0000-0002-9858-6083, Yasuo Murai, MD, PhD https://orcid.org/0000-0002-9753-1873, Akio Morita, MD, PhD https://orcid.org/0000-0002-2497-5772, and YasunariMano, RPh, PhDhttps://orcid.org/0000-0002-2245-4260 mano@rs.tus.ac.jp Author Info & Affiliations Stroke New online

https://doi.org/10.1161/STROKEAHA.124.049997

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Abstract

While the efficacy of statins, which are cholesterol-lowering agents, in preventing subarachnoid hemorrhage (SAH) has been examined in experimental animal models and some clinical studies, findings remain inconclusive. This study aimed to investigate the association between statin use and the risk of SAH.

METHODS:

We conducted a large population-based case-control study using data from the Japanese Health Insurance Claims Database from January 2005 to August 2021. This nationwide database includes the data of individuals aged 0 to 74 years. Cases were defined as patients hospitalized with a first diagnosis of SAH (International Classification of Diseases, Tenth Revision code I60) during this period. Four controls per case were randomly selected and matched by age, sex, and follow-up period using incidence density sampling. Statin exposure (use, recency, and duration) was evaluated before the incidence of SAH. Conditional logistic regression, adjusted for patient characteristics, was used to assess the association between statin use and SAH risk. We also investigated whether this association varies with a history of hypertension, diabetes, cerebrovascular disease, unruptured intracranial aneurysms, and the use of antihypertensive medications.

RESULTS:

The study identified 3498 cases and 13 992 matched controls. Statin use was reported in 12.2% of SAH cases and 12.7% of the controls. After adjusting for patient characteristics, statin use was associated with a significantly reduced risk of SAH (adjusted odds ratio, 0.81 [95% CI, 0.69–0.95]). The association was significantly influenced by a history of hypertension or cerebrovascular disease (P interaction=0.042 and 0.042, respectively).

CONCLUSIONS:

Statin use was significantly associated with a reduced risk of SAH. These findings suggest that statins may play a role in the prevention of SAH, particularly in patients with a history of hypertension or cerebrovascular disease.

Graphical Abstract