Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 32,185 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Saturday, July 12, 2025
Mild Behavioral Impairment and Cortical Thinning: Biomarkers of Early Neurodegeneration
Of course, your competent? doctor created a protocol to prevent cortical thinning and mild behavioral impairment years ago, right! Oh no, NOTHING OCCURRED!
Does your doctor even acknowledge that this is his/her responsibility? Or is head in the sand the first choice?
Mild Behavioral Impairment(MBI) is increasingly recognized as an early phenotypic marker of neurodegeneration, characterized by neuropsychiatric symptoms(NPS) emerging prior to overt cognitive decline. While structural neuroimaging studies link cortical thinning with NPS, the relationship between MBI and cortical morphology remains underexplored in diverse, community-based cohorts. This study investigated whether early behavioral alterations, assessed via the Mild Behavioral Impairment Checklist(MBI-C), correlate with region-specific cortical thinning in a Southeast Asian cohort.
Methods
A cross-sectional analysis was conducted on 969 participants (mean age 61.99±10.19years;39.6% male;87.2%Chinese) from the Biomarkers and Cognition Study in Singapore(BIOCIS), spanning cognitively normal, subjective cognitive decline(SCD), and mild cognitive impairment(MCI). MBI was assessed using self-reported MBI-C. Cortical thickness was measured using T1-weighted MRI scans processed with FreeSurfer. Associations between cortical thinning and MBI-C total and subdomain scores were evaluated.
Results
Higher scores on the MBI-C Belief subdomain were significantly associated with cortical thinning in the right hemisphere(β=–0.0177;95%CI:–0.0342to–0.0012;P=0.035). Region-specific analyses showed temporal lobe thinning in the posterior superior temporal sulcus, fusiform gyrus, superior temporal gyrus, temporal pole, and transverse temporal gyrus, and associations remained significant after false discovery rate(FDR) correction(P=0.042–0.045). Additional cortical thinning was observed in the right postcentral gyrus, supramarginal gyrus, and insula(FDR P≤0.039).
Conclusions
Elevated MBI, particularly abnormal beliefs, is linked to cortical thinning in regions subserving memory, sensory integration, and emotional regulation predominantly in the right hemisphere. These findings highlight the potential of MBI-C as an early neurodegenerative marker. Further longitudinal studies are needed to clarify temporal dynamics and mechanisms underlying behavioral symptoms and neurodegenerative processes.
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