Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, November 8, 2025

Small increases in daily steps may slow Alzheimer’s progression

 Your competent? doctor better get you recovered enough to do whatever number of steps you want.

Oh no, your doctors completely fucking failed at that task, and you haven't fired them yet?!

Well, there's all these other numbers for walking that your doctor already told you about, right? Choose one.

The latest here: 

Small increases in daily steps may slow Alzheimer’s progression

Increasing your steps by even a little bit may help slow down the progression of Alzheimer's disease among people at heightened risk, according to a new study. In a paper published in Nature Medicine, Mass General Brigham researchers found that physical activity was associated with slower rates of cognitive decline in older adults with elevated levels of amyloid-beta, a protein associated with Alzheimer's.

Cognitive decline was delayed by three years on average for people who walked just 3,000-5,000 steps per day, and by seven years in people who walked 5,000-7,500 steps per day. Sedentary individuals had a significantly faster buildup of tau proteins in the brain and more rapid declines in cognition and daily functioning.

This sheds light on why some people who appear to be on an Alzheimer's disease trajectory don't decline as quickly as others. Lifestyle factors appear to impact the earliest stages of Alzheimer's disease, suggesting that lifestyle changes may slow the emergence of cognitive symptoms if we act early."

Jasmeer Chhatwal, MD, PhD, senior author, Mass General Brigham Department of Neurology

The researchers analyzed data from 296 participants aged 50-90 years old in the Harvard Aging Brain Study who were all cognitively unimpaired at the beginning of the study. They used PET brain scans to measure baseline levels of amyloid-beta in plaques and tau in tangles and assessed the participants' physical activity using waistband pedometers. The participants received annual follow-up cognitive assessments for between two and 14 years (average = 9.3 years), and a subset received repeated PET scans to track changes in tau.

Higher step counts were linked to slower rates of cognitive decline and a slower buildup of tau proteins in participants with elevated baseline levels of amyloid-beta. The researchers' statistical modeling suggested that most of the physical activity benefits associated with slowing cognitive decline were driven by slower tau buildup. By contrast, in people with low baseline levels of amyloid-beta, there was very little cognitive decline or accumulation of tau proteins over time and no significant associations with physical activity.

 "We are thrilled that data from the Harvard Aging Brain Study has helped the field better understand the importance of physical activity for maintaining brain health," said co-author Reisa Sperling, MD, a neurologist in the Mass General Brigham Department of Neurology and co-principal investigator of the Harvard Aging Brain Study. "These findings show us that it's possible to build cognitive resilience and resistance to tau pathology in the setting of preclinical Alzheimer's disease. This is particularly encouraging for our quest to ultimately prevent Alzheimer's disease dementia, as well as to decrease dementia due to multiple contributing factors."

Looking ahead, the researchers plan to dive deeper into which aspects of physical activity may be most important, for example exercise intensity and longitudinal activity patterns. They also plan to investigate the biological mechanisms linking physical activity, tau buildup, and cognitive health. Critically, the authors believe that this work may help design future clinical trials that test exercise interventions to slow late-life cognitive decline, especially in individuals who are at heightened risk due to preclinical Alzheimer's disease.

"We want to empower people to protect their brain and cognitive health by keeping physically active," said first-author Wai-Ying Wendy Yau, MD, a cognitive neurologist in the Mass General Brigham Department of Neurology. "Every step counts - and even small increases in daily activities can build over time to create sustained changes in habit and health."

Source:

Mass General Brigham

Journal reference:

Yau, W.-Y. W., et al. (2025). Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease. Nature Medicine. doi.org/10.1038/s41591-025-03955-6

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