Real-world gait study of Parkinson’s disease using wearable sensors: a systematic review

 Your INCOMPETENT? DOCTOR isn't smart enough to use this to objectively identify your gait problems so EXACT PROTOCOLS can be used to correct them!

And your board of directors is so incompetent they can't recognize incompetence in their hospital!

Real-world gait study of Parkinson’s disease using wearable sensors: a systematic review

• Mona Michaud,
• Nicolas de l’Escalopier,
• Cyril Voisard,
• Laurent Oudre &
• Damien Ricard 

We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

Background

New technologies, such as wearable sensors, allow the quantitative assessment of gait alterations due to Parkinson’s disease (PD) through Digital Mobility Outcomes (DMOs). These DMOs have the potential to complement traditional clinical assessments but must be relevant, reliable, and representative of the patient’s overall condition. Real-world monitoring offers a valuable approach for this type of day-to-day evaluation of patients.

Objective

This systematic review has four primary aims: 1) To identify trends in protocol design for real-world gait monitoring using wearables in patients with PD. 2) To detail the analysis of inertial data and the computation of DMOs. 3) To summarize the clinical scales and symptoms studied. 4) To outline trends in the conclusions and limitations reported by authors in this field.

Methods

Three databases (MEDLINE via PubMed, Cochrane, and EMBASE) were systematically searched between September 1, 2013, and September 15, 2023. Eligibility criteria included studies involving adults with a PD diagnosis, the use of a wearable device with at least one accelerometer or gyroscope, and gait analysis conducted in real-world settings.

Results and conclusion

Sixty-three studies were selected. Overall, wearables successfully provide clinically meaningful information on gait impairment in patients with PD. Stride speed as a DMO is well-established and clinically meaningful, while other metrics, such as stride length, stride duration, and cadence, show great promise for routine clinical practice and research. However, the lack of consensus on the methods of investigation and the small sample sizes remain significant barriers that must be addressed to facilitate broader adoption in clinical practice and research.