Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 6, 2011

New drug development process

In one of the blogs I follow Stanford School of Medicine SCOPE, the discussion was on how drugs get to market. I was under the same impression as this blogger.
http://scopeblog.stanford.edu/archives/2011/05/re-engineering-the-drug-development-process.html
 I bolded it because it is so important to understand why we can't get acute stroke rehab drugs out there.
“I always sort of assumed that if I made a discovery that had immediate implications for new treatment for disease, big pharma would pick up on it and do the drug development step,” explained Ben A. Barres, Professor and Chair of Neurobiology at Stanford University School of Medicine, whose lab works with the M.R.F. “That’s infrequently the case. Usually things just sort of languish.” For a discovery to reach the threshold where a pharmaceutical company will move it forward what's needed is called "translational" research - research that validates targets and reduces the risk. This involves things like replicating and standardizing studies, testing chemicals (potentially millions) against targets, and if something produces a desired reaction, modifying compounds or varying concentration levels to balance efficacy and safety (usually in rats). It is repetitive, time consuming work - often described as "grunt work." It's vital for developing cures, but it's not the kind of research that will advance the career of a young scientist in a university setting.
"Pure science is what you're rewarded for," notes Dr. Barres. "That's what you get promoted for. That's what they give the Nobel Prizes for. And yet developing a drug is a hundred times harder than getting a Nobel Prize. We really have to have the very best scientists engaged in this. For a long time this hasn't been the case. Until five or ten years ago, working on disease was kind of shunned.”
In the end she discusses a unique collaboration effort to find MS drugs. Myelin Repair Foundation
We in the stroke world need something similar, or maybe we should get a major benefactor to devote some prize money to the best new drug. The current situation is pathetic.

This is why the Federal Research Center is so important, please contact the new director and explain the need for stroke rehab research, the unsexy kind.
http://oc1dean.blogspot.com/2011/04/federal-research-center-will-help.html
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