Methylphenidate(Ritalin) and stroke rehab

Methylphenidate is used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age) in adults and children.

Arch Phys Med Rehabil. 1998 Sep;79(9):1047-50.

Only 13 years old, I wonder what happened to further research.

http://www.ncbi.nlm.nih.gov/pubmed/9749682

Abstract

OBJECTIVE:

To determine the efficacy and safety of methylphenidate in acute stroke rehabilitation.

DESIGN:

A prospective, randomized, double-blind, placebo-controlled study.

PATIENTS AND SETTING:

Twenty-one stroke patients consecutively admitted to a community-based rehabilitation unit.

INTERVENTION:

Three-week treatment of methylphenidate (or placebo) in conjunction with physical therapy. Methylphenidate was started at 5mg and increased gradually to 30mg (15mg at 8:00AM and 15mg at 12:00 noon), and discontinued before discharge.

MAIN OUTCOME MEASURES:

Mood measures included the Hamilton Depression Rating Scale (HAM-D) and Zung Self-Rating Depression Scale (ZDS). Cognitive status was evaluated using the Mini-Mental State Exam (MMSE). Motor functioning was assessed using the Fugl-Meyer Scale (FMS) and a modified version of the Functional Independence Measure (M-FIM). All measures were administered pretreatment and weekly thereafter. Side effects were measured after each increase in dosage and weekly.

RESULTS:

Patients receiving methylphenidate treatment scored lower on the HAM-D (F(1,18)=5.714, p=.028), lower on the ZDS (F(1,18)=4.206, p=.055), higher on the M-FIM (F(1,18)=5.374, p=.032), and higher on the FMS (F(1,9)=4.060, p=.075) than patients receiving placebo.

CONCLUSION:

Methylphenidate appears to be a safe and effective intervention in early poststroke rehabilitation that may expedite recovery.