http://nnr.sagepub.com/content/26/4/325.abstract?etoc
Abstract
Background. Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke. Objective. The authors tested the hypothesis that motor recovery after hemiparetic stroke relates to changes in responsiveness of the
sensorimotor cortex (SMC) to somatosensory input. Methods.
A total of 10 hemiparetic stroke patients underwent serial functional
magnetic resonance imaging (fMRI) during tactile stimulation
and testing of sensorimotor function over 1 year—at
early subacute, late subacute, and chronic poststroke time points. Results.
Over the subacute poststroke period, increased responsiveness of the
ipsilesional SMC to tactile stimulation of a stroke-affected
digit correlated strongly with concurrent gains in
motor function. Increased responsiveness of the ipsilesional and
contralesional
SMC over the subacute period also correlated
strongly with motor recovery experienced over the first year poststroke.
Conclusions. These findings suggest that increased responsiveness of the SMC to somatosensory stimulation over the subacute poststroke
period may contribute to motor recovery.
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