Deans' stroke musings: Chewing during chronic stress ameliorates stress-induced suppression of neurogenesis in the hippocampal dentate gyrus in aged SAMP8 mice

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, July 2, 2012

Chewing during chronic stress ameliorates stress-induced suppression of neurogenesis in the hippocampal dentate gyrus in aged SAMP8 mice

So maybe the mice need to be chewing gum for mastication-induced arousal. Better blood flow to the brain.
h ttp://www.sciencedirect.com/science/article/pii/S0304394012008658

Abstract

Chronic stress suppresses neurogenesis in the hippocampal dentate gyrus (DG). Chewing under chronic stress is reported to suppress stress-induced responses. We examined whether chewing under restraint stress prevents restraint stress-induced suppression of neurogenesis in the hippocampal DG in aged senescence-accelerated prone (SAMP8) mice. Restraint stress increased plasma corticosterone levels, and suppressed cell proliferation, survival, and differentiation of newborn cells in the hippocampal DG. In contrast, chewing under restraint stress prevented the increase in plasma corticosterone levels, and ameliorated the suppression of cell proliferation, survival, and differentiation of newborn cells in the hippocampal DG. These results suggest that chewing under restraint stress prevents the stress-induced increase in plasma corticosterone levels, leading to the inhibition of stress-induced suppression of neurogenesis in the hippocampal dentate gyrus.

Highlights

► Effects of chewing under restraint stress on neurogenesis are not known. ► Chewing under stress prevents stress-induced increase in plasma corticosterone levels. ► Chewing under restraint stress ameliorates stress-induced suppression of neurogenesis. ► Chewing is a good strategy to cope with chronic stress.