Objective: The aim of this study was to evaluate the
relationship between body mass index (BMI) and change in motor
impairment and functional mobility after a gait rehabilitation
intervention in chronic stroke subjects.
Design: Correlation and linear regression analyses of
pretreatment and end-of-treatment Fugl-Meyer scores and modified Emory
Functional Ambulation Profile scores from hemiparetic subjects (n = 108,
>3 mos post stroke) who participated in a randomized controlled
trial comparing two 12-wk ambulation training treatments were generated.
Results: A series of linear regression models that
controlled for age, sex, stroke type, interval post-stroke, and training
device found the change in the Fugl-Meyer score to be significantly
negatively associated with pretreatment BMI ([beta] = -0.207, P = 0.036)
and the change in the "up and go" modified Emory Functional Ambulation
Profile score to be significantly positively associated with BMI ([beta]
= 0.216, P = 0.03). Changes in modified Emory Functional Ambulation
Profile scores in floor, carpet, obstacles, or stair climbing were not
significantly associated with BMI.
Conclusions: Chronic stroke subjects with a higher BMI
were less likely to demonstrate improvement in motor impairment and up
and go functional mobility performance in response to ambulation
training, irrespective of treatment intervention. Stroke rehabilitation
clinicians should consider BMI when formulating rehabilitation goals.
Further studies are necessary to determine whether obesity is a
predictor of longer-term post-stroke motor and functional recovery.
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