http://cshperspectives.cshlp.org/content/4/10/a008359.abstract
Abstract
The mammalian nervous system is the most
complex organ of any living organism. How this complexity is generated
during neural
development is just beginning to be elucidated.
This article discusses the signaling, transcriptional, and epigenetic
mechanisms
that are involved in neural development. The first
part focuses on molecules that control neuronal numbers through
regulation
of the timing of onset of neurogenesis, the timing
of the neuronal-to-glial switch, and the rate of progenitor
proliferation.
The second part focuses on molecules that control
neuronal diversity by generating spatially or temporally distinct
populations
of neuronal progenitors. Most of the studies
discussed in this article are focused on the developing mammalian
cerebral cortex,
because this is one of the main model systems for
neural developmental studies and many of the mechanisms identified in
this
tissue also operate elsewhere in the developing
brain and spinal cord.
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