Deans' stroke musings: Melatonin Potentiates Running Wheel-Induced Neurogenesis in the Dentate Gyrus of Adult C3H/HeN Mice Hippocampus

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, October 19, 2012

Melatonin Potentiates Running Wheel-Induced Neurogenesis in the Dentate Gyrus of Adult C3H/HeN Mice Hippocampus

Ask your doctor on this. No self-medication.
http://onlinelibrary.wiley.com/doi/10.1111/jpi.12023/abstract

Abstract

This study assessed the role of melatonin in modulating Running Wheel-induced (RW) hippocampal neurogenesis in adult C3H/HeN mice. Chronic melatonin (0.02 mg/ml, oral for 12 days) treatment did not affect cell proliferation or cell survival determined by the number of BrdU positive cells in dentate gyrus of mice with access to fixed wheel (FW). RW activity significantly increased cell proliferation [RW (n=8) vs. FW (n=6): dorsal, 199 ± 18 vs. 125 ± 12, p < 0.01; ventral, 211 ± 15 vs. 123 ± 13, p < 0.01] and newborn cell survival [RW (n=7) vs. FW (n=8): dorsal, 45 ± 8.5 vs. 15 ± 1.8, p < 0.01; ventral, 48 ± 8.1 vs. 15 ± 1.4)] in the dorsal and ventral dentate gyrus. Oral melatonin treatment further potentiated RW activity-induced cell survival in both areas of the dentate gyrus [melatonin (n=10) vs. vehicle (n=7): dorsal, 63 ± 5.4 vs. 45 ± 8.5 p < 0.05; ventral, 75 ± 7.9 vs. 48 ± 8.1, p < 0.01] and neurogenesis [melatonin (n=8) vs. vehicle (n=8): dorsal, 46 ± 3.4, vs. 34 ± 4.5, p < 0.05; ventral, 41 ± 3.4 vs. 25 ± 2.4, p < 0.01]. We conclude that melatonin potentiates RW induced hippocampal neurogenesis by enhancing neuronal survival suggesting that the combination of physical exercise and melatonin may be an effective treatment for diseases affecting the hippocampus neurogenesis.