Abstract
The Nobel laureate Max Delbrück often
said that it is the crossover between disciplines where advances are
possible in science.
This certainly has been true for our
understanding of the vascular biology of the central nervous system in
the setting of
ischemic stroke. The ability to cross the
boundaries of hemostasis, neurology, hematology, and neuroscience has
facilitated
our research direction to define the relation of
the microvasculature to neuron function. Work begun with the clinical
scientific
exploration of the contributions of arterial
thrombosis to the acute injury processes initiated by focal cerebral
ischemia
has led to an increased understanding of the
effects of ischemia on microvessel integrity.
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