http://www.sciencemag.org/content/338/6112/1303.short
The overarching strategy of all immune systems is as predictable as the plot of an episode of Mission: Impossible.
A short-lived message describing the problem reaches commanding immune
cells. A team of specialized expert cells is then
dispatched to deal with the problem. Once
successfully addressed, the team disappears without leaving a trace. On
page 1353
of this issue, Kyritsis et al. (1)
characterize an astonishing type of immune response—a new team of
“executioner” cells—that is implemented when the zebrafish
brain is injured. By tricking the immune system
into believing neuronal injury had occurred, the authors discovered that
inflammation
alone is sufficient to switch on neurogenesis.
The molecular components used by the highly specialized immune cells
that promote
neurogenesis represent potential novel
therapeutic targets that could promote brain repair.
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