http://circres.ahajournals.org/content/113/8/952.full.pdf+html
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Ok, I found the abstract;
Carcinoembryonic Antigen–Related Cell Adhesion Molecule 1 Inhibits MMP-9–Mediated Blood–Brain–Barrier Breakdown in a Mouse Model for Ischemic Stroke
Abstract
Rationale: Blood–brain–barrier (BBB) breakdown and cerebral edema result from postischemic inflammation and contribute to mortality and morbidity after ischemic stroke. A functional role for the carcinoembryonic antigen–related cell adhesion molecule 1 (CEACAM1) in the regulation of reperfusion injury has not yet been demonstrated.
Objective: We sought to identify and characterize the relevance of CEACAM1-expressing inflammatory cells in BBB breakdown and outcome
after ischemic stroke in Ceacam1−/− and wild-type mice.
Methods and Results:
Focal ischemia was induced by temporary occlusion of the middle
cerebral artery with a microfilament. metalloproteinase-9+ neutrophils in the ischemic hemispheres.
Conclusions:
CEACAM1 controls matrix metalloproteinase-9 secretion by neutrophils in
postischemic inflammation at the BBB after stroke.
We propose CEACAM1 as an important inhibitory
regulator of neutrophil-mediated tissue damage and BBB breakdown in
focal cerebral
ischemia.
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