Is this the breakthrough as to how neuroplasticity actually works for muscles? Ask your doctor if the Purkinje Cells are still working in your brain.
You do expect your doctor to know something about your damage, Don't you?
The article in Psychology Today here:
Neuroscientists Discover How Practice Makes Perfect
A more detailed writeup in Cell magazine here;
Sensory-Driven Enhancement of Calcium Signals in Individual Purkinje Cell Dendrites of Awake Mice
Highlights
- •Sensory events enhance climbing-fiber-triggered calcium spikes in Purkinje cells
- •The enhancement arises partly from sensory activation of a non-climbing-fiber source
- •The enhancement differentiates sensory-driven from spontaneous calcium spikes
Summary
Climbing
fibers (CFs) are thought to contribute to cerebellar plasticity and
learning by triggering a large influx of dendritic calcium in the
postsynaptic Purkinje cell (PC) to signal the occurrence of an
unexpected sensory event. However, CFs fire about once per second
whether or not an event occurs, raising the question of how
sensory-driven signals might be distinguished from a background of
ongoing spontaneous activity. Here, we report that in PC dendrites of
awake mice, CF-triggered calcium signals are enhanced when the trigger
is a sensory event. In addition, we show that a large fraction of the
total enhancement in each PC dendrite can be accounted for by an
additional boost of calcium provided by sensory activation of a non-CF
input. We suggest that sensory stimulation may modulate dendritic
voltage and calcium concentration in PCs to increase the strength of
plasticity signals during cerebellar learning. (This sounds like confirmation of what the 2001 Margaret Yekutiel book, 'Sensory Re-Education of the Hand After Stroke' says.)
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