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Dementia prevention 19 ways
Traumatic brain injury and risk of dementia in older veterans
- Deborah E. Barnes, PhD, MPH,
- Allison Kaup, PhD,
- Katharine A. Kirby, MA,
- Amy L. Byers, PhD, MPH,
- Ramon Diaz-Arrastia, MD, PhD and
- Kristine Yaffe, MD
- Correspondence to Dr. Barnes: Deborah.barnes@ucsf.edu
-
10.1212/WNL.0000000000000616Neurology
- Abstract
- Full Text (PDF)
- Also available:
- Accompanying Editorial
Abstract
Objectives:
Traumatic brain injury (TBI) is common in military personnel, and there
is growing concern about the long-term effects of
TBI on the brain; however, few studies have
examined the association between TBI and risk of dementia in veterans.
Methods: We
performed a retrospective cohort study of 188,764 US veterans aged 55
years or older who had at least one inpatient or
outpatient visit during both the baseline
(2000–2003) and follow-up (2003–2012) periods and did not have a
dementia diagnosis
at baseline. TBI and dementia diagnoses were
determined using ICD-9 codes in electronic medical records.
Fine-Gray proportional hazards models were used to determine whether TBI
was associated
with greater risk of incident dementia,
accounting for the competing risk of death and adjusting for
demographics, medical
comorbidities, and psychiatric disorders.
Results: Veterans
were a mean age of 68 years at baseline. During the 9-year follow-up
period, 16% of those with TBI developed dementia
compared with 10% of those without TBI (adjusted
hazard ratio, 1.57; 95% confidence interval: 1.35–1.83). There was
evidence
of an additive association between TBI and other
conditions on risk of dementia.
Conclusions: TBI in
older veterans was associated with a 60% increase in the risk of
developing dementia over 9 years after accounting
for competing risks and potential confounders.
Our results suggest that TBI in older veterans may predispose toward
development
of symptomatic dementia and raise concern about
the potential long-term consequences of TBI in younger veterans and
civilians.
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