http://www.neurology.org/content/83/1/19.abstract
- Zhizhong Zhang, MD, PhD*,
- Gelin Xu, MD, PhD*,
- Fang Yang, MD, PhD,
- Wusheng Zhu, MD, PhD and
- Xinfeng Liu, MD, PhD
- Correspondence to Dr. Liu: xfliu2@vip.163.com
-
July 1, 2014 vol. 83 no. 1 19-25Neurology
- Abstract
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Abstract
Objective: To perform a meta-analysis of prospective studies to evaluate the relation between dietary protein intake and stroke risk.
Methods: Relevant
studies were identified by searching PubMed and Embase through November
2013, and by reviewing the reference lists
of retrieved articles. We included prospective
cohort studies that reported relative risks (RRs) with 95% confidence
intervals
(CIs) for the association between dietary
protein intake and stroke risk.
Results: The
meta-analysis included 7 prospective studies involving 254,489
participants. The pooled RR of stroke for the highest
compared with the lowest dietary protein intake
was 0.80 (95% CI 0.66–0.99). Dose-response analysis indicated that a
20-g/d
increment in dietary protein intake was
associated with a 26% reduction in stroke risk. Stratifying by protein
type, the RR
of stroke for animal protein was 0.71 (95% CI
0.50–0.99). Sensitivity analysis restricted to studies with control for
common
risk factors yielded similar results, and
omission of any single study did not change the overall result.
Conclusion: These findings suggest that moderate dietary protein intake may lower the risk of stroke.
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