Whom is testing this for stroke? ASA? NSA? WSO?A year from now this still won't be tested because we have crap for stroke associations.
http://www.biosciencetechnology.com/news/2014/07/rotten-egg-gas-holds-key-healthcare-therapies?et_cid=4040319&et_rid=648870051&location=top
It may smell awful and have a
reputation for being highly toxic, but when used in the right tiny
dosage, hydrogen sulfide is now being found to offer potential health
benefits in a range of issues, from diabetes to stroke, heart attacks
and dementia.
A new compound (AP39), designed and made at the University of Exeter,
could hold the key to future therapies, by targeting delivery of very
small amounts of the substance to the right (or key) places inside
cells.
Scientists in Exeter have already found that the compound protects
mitochondria—the “powerhouse” of cells, which drive energy production in
blood vessel cells. Preventing or reversing mitochondrial damage is a
key strategy for treatments of a variety of conditions such as stroke,
heart failure, diabetes and arthritis, dementia and ageing. Mitochondria
determine whether cells live or die and they regulate inflammation. In
the clinic, dysfunctional mitochondria are strongly linked to disease
severity.
Professor Matt Whiteman, of the University of Exeter Medical School,
said: “When cells become stressed by disease, they draw in enzymes to
generate minute quantities of hydrogen sulfide. This keeps the
mitochondria ticking over and allows cells to live. If this doesn’t
happen, the cells die and lose the ability to regulate survival and
control inflammation. We have exploited this natural process by making a
compound, called AP39, which slowly delivers very small amounts of this
gas specifically to the mitochondria. Our results indicate that if
stressed cells are treated with AP39, mitochondria are protected and
cells stay alive.”
Dr. Mark Wood of Biosciences, at the University of Exeter, added
“Although hydrogen sulfide is well known as a pungent, foul-smelling gas
in rotten eggs and flatulence, it is naturally produced in the body and
could in fact be a healthcare hero with significant implications for
future therapies for a variety of diseases.”
The research is being conducted in several models of disease, and
pre-clinical results are promising. For example, in models of
cardiovascular disease, research shows that more than 80 per cent of the
powerhouse mitochondria cells survive under otherwise highly
destructive conditions, if the AP39 is administered. Professors
Whiteman and Wood are now working towards advancing the research to a
stage where it can be tested in humans.
The study was published in the journal Medicinal Chemistry
Communications. A follow-up study, published in The Nitric Oxide Journal
with collaborators from the University of Texas Medical Branch, also
found that the compound selectively prevented mitochondrial DNA in
mitochondria. Once damaged, this DNA cannot be repaired, leaving
individuals more vulnerable to disease symptoms.
Early indications in small-scale studies, presented at this year’s
3rd International Conference on Hydrogen Sulfide in Biology and Medicine
in Kyoto, also show that in high blood pressure, AP39 reversed blood
vessel stiffening and lowered blood pressure. It also dramatically
improved chances of survival after a heart attack by slowing the
heartbeat, improving its efficiency.
Source: University of Exeter
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,972 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Thursday, July 17, 2014
Rotten Egg Gas Holds Key to Healthcare Therapies
Labels:
AP39,
ASA,
clinical trials,
crap,
failure,
hydrogen sulfide,
hyperacute,
NSA,
stroke association,
WSO
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