Deans' stroke musings: ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, February 11, 2015

ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

So is your cognitive impairment post-stroke because of blood type AB rather than the stroke itself? What the hell does your doctor have to say? At least I'm O negative so all I have to worry about is getting needed blood from other O negative persons, A good friend has that type so I'll have to make sure I know where she is at all times, considering my dangerous predilictions.
http://www.neurology.org/content/83/14/1271

Kristine S. Alexander, PhD, MCR,
Neil A. Zakai, MD, MSc,
Sarah Gillett, PhD,
Leslie A. McClure, PhD,
Virginia Wadley, PhD,
Fred Unverzagt, PhD and
Mary Cushman, MD, MSc

+Show Affiliations

Correspondence to Dr. Cushman: mary.cushman@uvm.edu

Published online before print September 10, 2014, doi: 10.1212/WNL.0000000000000844 Neurology September 30, 2014 vol. 83 no. 14 1271-1276

Abstract

Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.

Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.

Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15–2.90; and 1.24, 95% CI 1.10–1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119–165) compared with O (104 IU/dL; 95% CI 101–107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation −30% to 68%).

Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.