Deans' stroke musings: Growth cones carve a path through tissues

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, February 21, 2015

Growth cones carve a path through tissues

We need this for our neurons that are trying to reconnect. What is your doctor doing to facilitate this research? Does your hospital have goals and objectives for each of its' neurologists to produce viable stroke research each year? If not, you need to call your hospital president and ask why their stroke department is so f*cking incompetent.
http://www.sciencemag.org/content/347/6224/837.5.full?utm_campaign=email-sci-ec&

Pamela J. Hines

Neural growth cones use invadopodia-like fingers to push through tissues

PHOTO: TIMOTHY GOMEZ

A growth cone leading a neuron's development needs more than muscle to push its way through tissues and across boundaries. Santiago-Medina et al. found features on neuronal growth cones that are like the invadosomes of immune and metastatic cancer cells, which themselves have a knack for squeezing through existing tissues. These invadosomes, fingers that poke out into the surrounding tissue, are packed with cytoskeleton and exude proteases that degrade the extracellular matrix. The invadosomes were key for Xenopus motoneurons trying to find a path out of the spinal cord and into the developing musculature.

Development 10.1242/dev.108266 (2015).