Deans' stroke musings: Pericytes in Vascular Development and Function

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, October 13, 2015

Pericytes in Vascular Development and Function

This is vastly important for your doctor to understand. What is your doctor doing about pericytes strangling small capillaries in the aftermath of your stroke?
Capillaries that don't open due to pericytes not letting go.

http://link.springer.com/chapter/10.1007/978-1-4939-2907-8_3

Richard Daneman
, Annika Keller

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Abstract

Pericytes are perivascular cells that line the abluminal surface of the microvasculature. Recent years have witnessed tremendous progress in understanding the function of these cells. Pericytes have emerged as important regulators of vascular development and homeostasis. In addition, pericytes possess several organ-specific functions, including regulation of blood flow and modulation of the immune response. Pericytes are also emerging as therapeutic targets in pathological conditions such as tissue fibrosis, stroke, and tumors. In this chapter, we provide an overview of the ontogeny and morphology of pericytes, signaling pathways critical for pericyte recruitment to developing vessels, and various physiological roles of pericytes.