Deans' stroke musings: A novel SPECT-based approach reveals early mechanisms of central and peripheral inflammation after cerebral ischemia

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, December 8, 2015

A novel SPECT-based approach reveals early mechanisms of central and peripheral inflammation after cerebral ischemia

So maybe SPECT scans can be useful as compared to Dr. Amens use of them.
http://www.nature.com/jcbfm/journal/v35/n12/full/jcbfm2015174a.html

Krisztián Szigeti¹, Ildikó Horváth¹, Dániel S Veres¹, Bernadett Martinecz², Nikolett Lénárt², Noémi Kovács³, Erika Bakcsa¹, Alexa Márta¹, Mariann Semjéni³, Domokos Máthé³ and Ádám Dénes²

¹Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary
²Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary
³CROmed Translational Research Centers, Budapest, Hungary

Correspondence: Dr A Denes, Laboratory of Neuroimmunology, Institute of Experimental Medicine, Szigony u. 43, IX. Tuzoltó u. 37-47, Budapest 1083, Hungary. E-mail: denesa@koki.hu

Received 23 April 2015; Revised 8 June 2015; Accepted 17 June 2015
Advance online publication 29 July 2015

Top

Abstract

Inflammation that develops in the brain and peripheral organs after stroke contributes profoundly to poor outcome of patients. However, mechanisms through which inflammation impacts on brain injury and overall outcome are improperly understood, in part because the earliest inflammatory events after brain injury are not revealed by current imaging tools. Here, we show that single-photon emission computed tomography (NanoSPECT/CT Plus) allows visualization of blood brain barrier (BBB) injury after experimental stroke well before changes can be detected with magnetic resonance imaging (MRI). Early 99mTc-DTPA (diethylene triamine pentaacetic acid) signal changes predict infarct development and systemic inflammation preceding experimental stroke leads to very early perfusion deficits and increased BBB injury within 2 hours after the onset of ischemia. Acute brain injury also leads to peripheral inflammation and immunosuppression, which contribute to poor outcome of stroke patients. The SPECT imaging revealed early (within 2 hours) changes in perfusion, barrier function and inflammation in the lungs and the gut after experimental stroke, with good predictive value for the development of histopathologic changes at later time points. Collectively, visualization of early inflammatory changes after stroke could open new translational research avenues to elucidate the interactions between central and peripheral inflammation and to evaluate in vivo ‘multi-system’ effects of putative anti-inflammatory treatments.

Complete article available at the link.