Deans' stroke musings: A protein assist for brain border crossings

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 9, 2016

A protein assist for brain border crossings

So when we finally do get drugs that help us recover your doctor can decide between these four ways to cross the blood brain barrier. Does your doctor know about ANY of these? If your stroke department doesn't sponsor research they shouldn't even be in the stroke rehab business. Call the president on that.

Blood-brain Barrier Opened Non-invasively for the First Time - Ultrasound

Smuggling Drugs into the Brain: An Overview of Ligands Targeting... (2015)

Nanorobotic agents open the blood-brain barrier, offering hope for new brain treatments

A protein assist for brain border crossings

Kristen L. Mueller

Getting therapies into the brain represents a major challenge to drug developers. A layer of brain endothelial cells (BECs) acts as a barrier by preventing large molecules in the blood from accessing the brain. One promising way to overcome this is by using protein receptors on BECs to transfer large molecules like antibodies across the barrier. Zuchero et al. used proteomics to identify candidate proteins expressed highly on mouse BECs. They found that BECs expressed high amounts of CD98hc and then created antibodies to target it. These antibodies could access the brain after systemic dosing of mice and showed substantial pharmacodynamic activity after being engineered so that one antibody arm recognized a potential drug target for Alzheimer's disease.

Neuron 10.1016/j.neuron.2015.11.024 (2016).