Deans' stroke musings: Remodeling of Neuronal Circuits After Reach Training in Chronic Capsular Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, May 19, 2016

Remodeling of Neuronal Circuits After Reach Training in Chronic Capsular Stroke

Whatever a capsular stroke is it seems you need at least some of the area still alive in order to recover that function. So DEMAND your doctor tell you those areas that still have some left in order to focus recovery training protocols on those. So if you are like me and decided to completely kill off huge areas of the brain there is no help for you in this research. Solving that is a BHAG(Big Hairy Audacious Goal) that is unlikely to ever be researched unless a survivor is leading the strategy.
http://nnr.sagepub.com/content/early/2016/05/17/1545968316650282.abstract?&

¹Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
²Douglas Mental Health University Institute, Montréal, Canada
³Chonnam National University Medical School, Gwangju, Republic of Korea
⁴Presbyterian Medical Center, Jeonju, Republic of Korea

Hyoung-Ihl Kim, MD, Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, 261 Cheomdan-gwagiro, Gwangju, 500-712, South Korea. Email: hyoungihl@gist.ac.kr

Abstract

Background. Subcortical capsular stroke has a poor prognosis, and it is not yet fully understood how and under what circumstances reach training contributes to motor recovery.

Objective. This study was performed to investigate changes in neuronal circuits and motor recovery in a chronic capsular stroke model in the presence or absence of reach training.

Method. We generated photothrombotic capsular lesions in 42 Sprague-Dawley rats and evaluated motor recovery with or without daily training in a single-pellet reaching task (SPRT). We used 2-deoxy-2-[18F]-fluoro-D-glucose-microPET (positron emission tomography) to assess remodeling of neuronal circuits.

Results. SPRT training was selectively beneficial only for the group with incomplete capsular destruction (P < .05), suggesting the relevance of plasticity in the remaining capsular fibers for motor recovery. Groups that did not receive SPRT training showed no motor recovery at all. The microPET analysis demonstrated that motor recovery was correlated with a reduction in cortical diaschisis in ipsilesional motor and sensory cortices and in the contralesional sensory cortex (Pearson’s correlation, P < .05). We also observed training-dependent subcortical activation in the contralesional red nucleus, the internal capsule, and the ventral hippocampus (P < .0025; false discovery rate q < 0.05). The groups without reach training did not show the same degree of reduction in diaschisis or activation of the red nucleus. Conclusions. Our results suggest that motor recovery and remodeling of neuronal circuits after capsular stroke depend on the magnitude of the capsular lesion and on the presence or absence of reach training. Task-specific training is strongly indicated only when there is incomplete destruction of the capsular fibers.