How the review was done
- most people had high blood pressure; some had diabetes, chronic kidney disease, or more than one condition that increased risk for cardiovascular events;
- drugs were used to reduce blood pressure to specific levels or by specific amounts;
- more-intensive therapy was compared with less-intensive therapy;
- more-intensive therapy aimed to reduce blood pressure more than less-intensive therapy; and
- people were followed up for at least 6 months (3.8 years on average).
What the researchers found
- reduced blood pressure (SBP by 6.8 mm Hg and DBP by 3.5 mm Hg);
- reduced major cardiovascular events and stroke;
- had similar rates of death, heart attack, heart failure, and end-stage kidney disease; and
- had higher rates of severe low blood pressure, which can cause dizziness or fainting, although yearly event rates were low in both groups (0.1% in the lower-intensity group vs 0.3% in the higher-intensity group, with adverse events leading to discontinuation of treatment in 1% for each group).