Hypothermia After Stroke Reduces Dynamin Levels and Neuronal Cell Death

I haven't been able to figure out if hypothermia is good for stroke survivors. Nothing is clear in the 37 posts I've written on hypothermia. If we had a great stroke association all stroke research would be publicly available and summarized as to applicability to stroke recovery. But instead we have fucking ABSOLUTELY NOTHING.

Hypothermia After Stroke Reduces Dynamin Levels and Neuronal Cell Death

16 August 2017 Mary Ann Liebert, Inc., Publishers

A new study has shown that following brain ischemia caused by cerebral blockage in mice both immediate and delayed reduction in body temperature helped limit cell death and levels of a protein called dynamin. These results, which suggest that dynamin may have a role in-and be a potential drug target for-stroke-related neuronal cell death, are reported in Therapeutic Hypothermia and Temperature Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal website until September 16, 2017.

The article entitled "Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke" is coauthored by Jong Youl Kim, PhD, Nuri Kim, Jong Eun Lee, PhD, and Midori Yenari, MD, University of California, San Francisco and Yonsei University College of Medicine, Seoul, Republic of Korea.

The researchers demonstrated increased expression of dynamin and the cell surface receptor FAS in a mouse model of stroke. They assessed the effects of two cooling approaches on the survival of brain cells: cooling as soon as cerebral blockage occurs (early hypothermia) and cooling that began 1 hour later (delayed hypothermia). The results were compared to those in mice not subjected to hypothermia.

"These exciting results present new injury pathways to target for utilizing therapeutic hypothermia in acute as well as sub-acute time points after stroke," says W. Dalton Dietrich, III, PhD, Editor-in-Chief of Therapeutic Hypothermia and Temperature Management, Scientific Director of The Miami Project to Cure Paralysis, and Kinetic Concepts Distinguished Chair in Neurosurgery, University of Miami Leonard M. Miller School of Medicine.
http://online.liebertpub.com/doi/full/10.1089/ther.2017.0005

Attached files

• Therapeutic Hypothermia and Temperature Management
  

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• Full bibliographic informationThe article entitled "Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke" is coauthored by Jong Youl Kim, PhD, Nuri Kim, Jong Eun Lee, PhD, and Midori Yenari, MD, University of California, San Francisco and Yonsei University College of Medicine, Seoul, Republic of Korea.
  
  To cite this article:
  Kim Jong Youl, Kim Nuri, Lee Jong Eun, and Yenari Midori A.. Therapeutic Hypothermia and Temperature Management. June 2017, ahead of print. https://doi.org/10.1089/ther.2017.0005