https://www.mdlinx.com/internal-medicine/top-medical-news/article/2017/12/20/7498233/?
Reuters Health News
The use of anti-hyperglycemic agents is associated with a reduced risk of intracranial aneurysm rupture, according to a medical records study.
"This study suggests that anti-hyperglycemic medications may be potential therapeutic agents for the prevention of aneurysm rupture,” Dr. Rose Du from Brigham and Women's Hospital, Harvard Medical School, Boston, told Reuters Health by email. “However, future studies will be required to understand the mechanism behind this association, and prospective clinical studies will be required to confirm the protective effects.”
Some reports have suggested that diabetes could be a protective factor for rupture of intracranial aneurysms, but the findings are inconsistent.
Dr. Du’s team investigated the possible association of hemoglobin A1c (HbA1c) values and the use of anti-hyperglycemic agents with the risk of intracranial aneurysm rupture in a study of medical records from 4,701 patients with 6,411 aneurysms, of which 1,302 (28%) were ruptured.
The findings were published online December 4 in Stroke.
Anti-hyperglycemic use was associated with a 43% lower risk of intracranial aneurysm rupture in multivariate analysis. Also independently associated with a lower rupture risk were female sex and a family history of aneurysm.
Factors independently associated with a significantly higher risk of rupture included black, Hispanic, Asian, or "other" race, as well as current alcohol and tobacco use.
HbA1c values were not significantly associated with the risk of aneurysm rupture.
“We were surprised to find that it was the use of anti-hyperglycemic agents rather than the hyperglycemia itself that is inversely associated with aneurysm rupture,” Dr. Du said.
She cautioned, “We would like to point out that while the results of this study showed an association between anti-hyperglycemic agents and decreased risk of aneurysm rupture, it would be important not to assume causation without additional studies.”
—Will Boggs, MD
"This study suggests that anti-hyperglycemic medications may be potential therapeutic agents for the prevention of aneurysm rupture,” Dr. Rose Du from Brigham and Women's Hospital, Harvard Medical School, Boston, told Reuters Health by email. “However, future studies will be required to understand the mechanism behind this association, and prospective clinical studies will be required to confirm the protective effects.”
Some reports have suggested that diabetes could be a protective factor for rupture of intracranial aneurysms, but the findings are inconsistent.
Dr. Du’s team investigated the possible association of hemoglobin A1c (HbA1c) values and the use of anti-hyperglycemic agents with the risk of intracranial aneurysm rupture in a study of medical records from 4,701 patients with 6,411 aneurysms, of which 1,302 (28%) were ruptured.
The findings were published online December 4 in Stroke.
Anti-hyperglycemic use was associated with a 43% lower risk of intracranial aneurysm rupture in multivariate analysis. Also independently associated with a lower rupture risk were female sex and a family history of aneurysm.
Factors independently associated with a significantly higher risk of rupture included black, Hispanic, Asian, or "other" race, as well as current alcohol and tobacco use.
HbA1c values were not significantly associated with the risk of aneurysm rupture.
“We were surprised to find that it was the use of anti-hyperglycemic agents rather than the hyperglycemia itself that is inversely associated with aneurysm rupture,” Dr. Du said.
She cautioned, “We would like to point out that while the results of this study showed an association between anti-hyperglycemic agents and decreased risk of aneurysm rupture, it would be important not to assume causation without additional studies.”
—Will Boggs, MD
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