No point in getting the actual article after reading this abstract. I can't even figure out whom this is written for unless it is someone with zero knowledge of stroke.
https://link.springer.com/chapter/10.1007/978-981-10-5804-2_26
Chapter
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Abstract
Animal
models of ischemic, hemorrhagic stroke and transformation certainly
have vivid importance for clinical studies and development of
thrombolytic as well as neuroprotective drugs. Clear understanding of
techniques for every type of stroke modeling highlights naturally
impossible adverse effects of the surgery, which might greatly influence
the interpretation of final experimental results. There are no stroke
models that fully reflect human disease. Infarcts are relatively larger
in experimental animals than in humans with strokes. The models are more
analogous to massive hemispheric infarcts than to localized strokes
such as those in the internal capsule. Every type of animal stroke model
is a partial hallmark of clinical picture. Thus, knowledge about the
variety of stroke models allows choosing the system, which will serves
for testing drugs or compound, predicting effective doses, and
evaluating possible adverse effects, pharmacokinatics. Clinical trials
might be more informative and successful if benchtop results are clearly
delineated and reflect treatment time window, mechanism, and doses.
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