Deans' stroke musings: Stroke repair: study shows a single pathway crucial for generating new stem cells, neurons and blood vessels

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, December 18, 2017

Stroke repair: study shows a single pathway crucial for generating new stem cells, neurons and blood vessels

Now we just need more followup to get this into a protocol with defined diagnosis entry points. Which will never occur, unless YOU have the money to hire researchers to accomplish that. Our fucking failures of stroke associations will once again do nothing and let possible solutions slip away.
http://www.canadianstroke.ca/en/news/stroke-repair-study-shows-a-single-pathway-crucial-for-generating-new-stem-cells-neurons-and-blood-vessels/

Pictured above: Dr. Jing Wang of the University of Ottawa and the Ottawa Hospital Research Institute
If you were to suffer a stroke, would you want your brain to create more stem cells, replace the damaged neurons or repair the broken blood vessels?
A new study led by Dr. Jing Wang shows that fine tuning a single molecular pathway may allow the brain to accomplish all three of these crucial tasks.
The study, published in Stem Cell Reports, focuses on a pathway called aPKC-CBP. Dr. Wang and her colleagues found that blocking this pathway early after a stroke can stimulate pericytes (which wrap around blood vessels in the brain) to become stem cells.(Will this also stop pericytes from strangling neurons in the neuronal cascade of death?)
But if you permanently block the pathway, it prevents the stem cells from becoming neurons and exhausts the pericytes so they can’t help with blood vessel repair during the chronic phase after a stroke. The paper thus suggests that the aPKC-CBP pathway may need to be blocked at the early phase of a stroke, then reactivated during the chronic phase of a stroke to get the optimal mix of cells for stroke repair and functional recovery. While this research was done in laboratory models, compounds that target the aPKC-CBP pathway are already being tested in human clinical trials for other conditions.
Authors: Gouveia A, Seegobin M, Kannangara TS, He L, Wondisford F, Comin CH, Costa LDF, Béïque JC, Lagace DC, Lacoste B, Wang J.
Funding: This research was possible because of generous donations to The Ottawa Hospital for Regenerative Medicine research. The researchers also received support from the J.P. Bickell Foundation, the Heart and Stroke Foundation (HSF), the HSF Canadian Partnership for Stroke Recovery and the Canadian Institutes of Health Research.