Useless. NOTHING on how to prevent this from happening. A hell of a lot of mentors and senior researchers need retraining on the point of stroke research. Helping stroke survivors, usually to 100% recovery.
Longer term stroke risk in intracerebral haemorrhage survivors
Abstract
Objective To evaluate the influence of intracerebral haemorrhage (ICH) location on stroke outcomes.
Methods
We included patients recruited to a UK hospital-based, multicentre
observational study of adults with imaging confirmed spontaneous ICH.
The outcomes of interest were occurrence of a cerebral ischaemic event
(either stroke or transient ischaemic attack) or a further ICH following
study entry. Haematoma location was classified as lobar or non-lobar.
Results
All 1094 patients recruited to the CROMIS-2 (Clinical Relevance of
Microbleeds in Stroke) ICH study were included (mean age 73.3 years;
57.4% male). There were 45 recurrent ICH events (absolute event rate
(AER) 1.88 per 100 patient-years); 35 in patients presenting with lobar
ICH (n=447, AER 3.77 per 100 patient-years); and 9 in patients
presenting with non-lobar ICH (n=580, AER 0.69 per 100 patient-years).
Multivariable Cox regression found that lobar ICH was associated with
ICH recurrence (HR 8.96, 95% CI 3.36 to 23.87, p<0.0001); similar
results were found in multivariable completing risk analyses. There were
70 cerebral ischaemic events (AER 2.93 per 100 patient-years); 29 in
patients presenting with lobar ICH (AER 3.12 per 100 patient-years); and
39 in patients with non-lobar ICH (AER 2.97 per 100 patient-years).
Multivariable Cox regression found no association with ICH location (HR
1.13, 95% CI 0.66 to 1.92, p=0.659). Similar results were seen in completing risk analyses.
Conclusions
In ICH survivors, lobar ICH location was associated with a higher risk
of recurrent ICH events than non-lobar ICH; ICH location did not
influence risk of subsequent ischaemic events.
Trial registration number NCT02513316.
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