Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, March 8, 2023

Incident Cognitive Impairment Tied to Stress

The reason all stroke survivors have so much stress is because their incompetent doctors have NO protocols that will get them to 100% recovery! It's not perceived stress, it's real stress that survivors have.

Chronic stress(How am I going to recover?) is directly your doctor's responsibility to solve. THE SOLUTION IS 100% RECOVERY PROTOCOLS, not guidelines or the crapola saying; 'All strokes are different, all stroke recoveries are different'. If that saying comes out of your doctor's mouth, you don't have a functioning stroke doctor, fire them.

Incident Cognitive Impairment Tied to Stress

More than one in five older adults report high levels of perceived stress

A photo of a worried-looking senior woman sitting at a table next to a window.

Perceived stress was linked with both prevalent and incident cognitive impairment in older adults, data from a national longitudinal cohort study showed.

Elevated levels of perceived stress -- dichotomized as low versus high stress scores -- were associated with higher odds of poor cognition after adjusting for sociodemographic variables, cardiovascular risk factors, and depression (adjusted OR 1.37, 95% CI 1.22-1.53), according to Ambar Kulshreshtha, MD, PhD, of Emory University School of Medicine in Atlanta, and co-authors.

Similarly, high stress levels were associated with incident cognitive impairment (adjusted OR 1.39, 95% CI 1.22-1.58), the researchers reported in JAMA Network Openopens in a new tab or window. There was no interaction with age, race, or sex.

In the cohort of 24,448 people with a median age of 64, a total of 5,589 people (22.9%) reported high levels of stress.

"Perceived stress is common among older adults, and it has been previously associated with accelerated aging, heart disease, and reduced immunity," Kulshreshtha noted.

"Our research in a large longitudinal study shows that perceived stress can be associated with cognitive decline," he told MedPage Today. "Given that there are very limited treatment options for dementia, research on how we can prevent this condition by addressing modifiable risk factors such as stress is critical."

Clinicians should screen for high levels of stress in older adults, Kulshreshtha added. "Brief questionnaires like the Perceived Stress Scale can be readily deployed in clinical practice," he said. "Even asking one question routinely -- how do you manage your stress? -- can be very helpful for patients to open up and discuss this common condition."

A study in Finland recently suggested that dementia risk was higher in people who had signs of stress and anxietyopens in a new tab or window earlier in life. Other research tied patterns of repeated rumination or worryopens in a new tab or window with subsequent declines in global cognition, immediate memory, and delayed memory.

Perceived stress occurs when demands exceed a person's professed ability to cope and has been linked with hormonal and inflammatory indicators of accelerated aging and excess cardiovascular morbidity and mortality risks, Kulshreshtha and colleagues noted.

"Perceived stress, especially in racial and ethnic minority groups, can directly affect cognition and also plays a role in worsening of unhealthy behaviors, such as smoking, physical inactivity, and reduced medication compliance," the team observed.

Kulshreshtha and co-authors evaluated participants in the REGARDSopens in a new tab or window study of Black and white Americans 45 or older. REGARDS participants were recruited from 2003 to 2007 and had annual follow-up. Data were collected by phone calls, self-administered questionnaires, and in-home exams.

The researchers measured stress with the 4-item version of the Perceived Stress Scaleopens in a new tab or window (PSS) at baseline and during one follow-up visit. Scores on the PSS range from 0-16; a score of 5 or more was considered high.

The Six-Item Screeneropens in a new tab or window (SIS) was used to assess cognitive function. Scores range from 0 to 6, and participants with an SIS score below 5 were considered to have cognitive impairment. Incident cognitive impairment was defined as a shift from intact cognition (SIS score of 5 or 6) at the first assessment to impaired cognition (score of 4 or less) at the most recent one.

The sample included 41.6% Black and 58.4% white participants. Most participants (59.9%) were women.

Participants with higher perceived stress scores were more likely to be younger, female, and Black, less likely to have a college degree, and had lower family income. They more frequently had cardiovascular disease risk factors such as hypertension, diabetes, and dyslipidemia. They were less physically active, had a higher body mass index, and more often were current smokers.

"While eliminating stress is not always possible, clinicians can help people develop healthier responses to stress using approaches such as mindfulness, a healthier lifestyle including physical activity and good sleep, and counseling," Kulshreshtha said.

Stress and depressive symptoms in this study were measured with validated but abbreviated versions of lengthier questionnaires, the researchers acknowledged. Unmeasured confounders could potentially explain associations between stress and cognition. Reverse causality could, too, but that was less likely given that the study was longitudinal and a clear dose response was seen between perceived stress and worse cognitive impairment, the team added.

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

Disclosures

This work was supported by the National Institute of Neurological Disorders and Stroke (NINDS).

Kulshreshtha and co-authors had no relevant disclosures.

Primary Source

JAMA Network Open

Source Reference: opens in a new tab or windowKulshreshtha A, et al "Association of stress with cognitive function among older Black and white U.S. adults" JAMA Netw Open 2023; DOI: 10.1001/jamanetworkopen.2023.1860.

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