Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, July 12, 2025

Smart micro/nanorobots for drug delivery in the brain

 Of course, your competent? doctor has been enabling research into nanobots for a long time already! NO? So, you don't have a functioning stroke doctor or hospital?

We should have been using magnetic nanoparticles to deliver tPA for years.

Or maybe this solution from March, 2015

Magnetic nanoparticles could stop blood clot-caused strokes

Or this from  May, 2012

Future of med devices: Nanorobots in your blood stream

 

The fucking answers are out there; they just need to be implemented.  

The latest here:

Smart micro/nanorobots for drug delivery in the brain


https://doi.org/10.1016/j.pmatsci.2025.101533Get rights and content
Under a Creative Commons license
Open access

Abstract

Pharmacotherapy is the core approach for treating various brain diseases. However, the intricate anatomical structure and the blood–brain barrier (BBB) of the brain present challenges for intracerebral drug delivery and therapeutic efficacy. Although systemic administration and surgical interventions can alleviate symptoms, they are limited by low therapeutic effects and potential adverse side effects. Moreover, due to their complex pathogenesis, insidious development, and deep-seated lesions, brain diseases are difficult to diagnose accurately. To address these challenges, there is an urgent need to develop intelligent nanocarriers that can efficiently load drugs and penetrate the BBB for precise therapy of brain diseases. In this connection, micro/nanorobots (MNRs) are multifunctional drug carriers at the micro-nano scale, which possess exceptional penetration and targeting capabilities. Employing externally powered propulsion or chemical self-propulsion, MNRs can navigate in the brain and cross the BBB. This review comprehensively summarizes the recent advances and future outlook of smart MNR drug delivery systems for brain disease treatment. It covers broad topics from nanocarriers to active smart MNRs. Furthermore, it elucidates the therapeutic mechanisms of these smart MNR drug delivery systems in brain diseases based on pathogenesis and pathology. Our aim is to provide a reference for designing and developing novel smart MNRs for drug delivery in the brain, paving the way for their clinical applications in treating brain diseases.
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