Deans' stroke musings: Prefrontal Cortex as a Central Hub of Structural Diaschisis Following Subcortical Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, October 1, 2025

Prefrontal Cortex as a Central Hub of Structural Diaschisis Following Subcortical Stroke

You created nothing here that gets survivors recovered! Here is how fucking long this has been out there; WITH NOTHING BEING DONE TO GET SURVIVORS RECOVERED!

The Role of Diaschisis in Stroke Recovery March 2018

The latest useless crapola here:

Prefrontal Cortex as a Central Hub of Structural Diaschisis Following Subcortical Stroke

Yuanyuan Li, MD https://orcid.org/0009-0002-9403-9805, Xinyue Shi, MD https://orcid.org/0009-0008-8174-5077, Yan Shen, MD, Linlu Wu, MB, Xirui Sun, MB, Kang Wu, MD, PhD, Kuangshi Li, MD, PhD https://orcid.org/0000-0001-7998-269X, … Show All … , and Yihuai Zou, MD, PhD https://orcid.org/0000-0002-4003-8244 zouyihuai2004@163.comAuthor Info & Affiliations

Stroke

New online

https://doi.org/10.1161/STROKEAHA.125.051768

Abstract

BACKGROUND:After a subcortical stroke, structural and functional alterations have often been observed in brain regions far from the lesion, a phenomenon suspected but not yet confirmed as diaschisis. This study investigated the existence and patterns of diaschisis following subcortical stroke.

METHODS:This observational, single-center, cross-sectional study was conducted in China from August 2014 to September 2023. We recruited patients with subcortical stroke with hemiplegia and unilateral lesions in the basal ganglia and corona radiata. Healthy controls were recruited from the community using an age- and sex-matching strategy with the patients. Patients were categorized by the National Institutes of Health Stroke Scale scores: mild (<5) and moderate (5–15) deficits. Using magnetic resonance imaging techniques, we analyzed gray matter volume alterations with voxel-based morphometry and causal structural networks with the causal structural covariance network method.

RESULTS:Of the 566 patients initially screened, 102 were enrolled. Due to recruitment constraints, only 46 healthy controls were recruited, limiting successful matching. The final analysis included 90 patients and 44 controls. The patient group (62 males and 28 females) had a mean age of 60.64±9.93 years, while the healthy group (23 males and 21 females) had a mean age of 59.43±5.01 years. We found significant gray matter volume loss in the medial superior frontal gyrus and identified both positive and negative directional connectivity patterns between this region and other areas in the prefrontal cortex (inferior frontal gyrus), temporal regions (superior and middle temporal gyri), limbic structures (insula, cingulate gyrus, and parahippocampus), and precentral. Notably, the causal network in patients with mild deficits was more complex.These findings support the existence of structural diaschisis following subcortical stroke, centered in the prefrontal cortex. This study underscores the importance of brain-wide imaging markers and may contribute to developing brain stimulation targets.