This sounds important but I'll have to leave the full 14 pages to researchers to propose uses for this knowledge.
http://www.ajsc.us/files/AJSC1205003.pdf
Abstract: Meninges are a three tissue membrane primarily known as coverings of the brain. More in depth studies on
meningeal function and ultrastructure have recently changed the view of meninges as a merely protective membrane.
Accurate evaluation of the anatomical distribution in the CNS reveals that meninges largely penetrate inside
the neural tissue. Meninges enter the CNS by projecting between structures, in the stroma of choroid plexus and form
the perivascular space (Virchow-Robin) of every parenchymal vessel. Thus, meninges may modulate most of the
physiological and pathological events of the CNS throughout the life. Meninges are present since the very early embryonic
stages of cortical development and appear to be necessary for normal corticogenesis and brain structures
formation. In adulthood meninges contribute to neural tissue homeostasis by secreting several trophic factors including
FGF2 and SDF-1. Recently, for the first time, we have identified the presence of a stem cell population with neural
differentiation potential in meninges. In addition, we and other groups have further described the presence in meninges
of injury responsive neural precursors. In this review we will give a comprehensive view of meninges and their
multiple roles in the context of a functional network with the neural tissue. We will highlight the current literature on
the developmental feature of meninges and their role in cortical development. Moreover, we will elucidate the anatomical
distribution of the meninges and their trophic properties in adult CNS. Finally, we will emphasize recent evidences
suggesting the potential role of meninges as stem cell niche harbouring endogenous precursors that can be
activated by injury and are able to contribute to CNS parenchymal reaction.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,294 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Saturday, June 16, 2012
Meninges: from protective membrane to stem cell niche
Labels:
FGF2,
meninges,
research,
SDF1,
stem cells,
trophic properties
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