Now all we need is some drug that actually either helps neurogenesis, angiogenesis, or neuroplasticity and we have the delivery system to get it there. And with magnetic ones we can deliver to specific areas. Who needs to be talked to to figure out next steps? God, this is so obvious.
Ranting again, time to let the medical gods sit back and do nothing. WSO - Bo Norrving where are you?
Can any of my Swedish readers see if he can talk to survivors about what he does for the WSO? Does he need help in figuring out where stroke research should go next?
http://www.dovepress.com/articles.php?article_id=10255
Purpose: Therapy for central
nervous system disease is mainly restricted by the blood–brain barrier. A
drug-delivery system is an effective approach to overcome this barrier.
In this research, the potential of polymeric micelles for
brain-targeting drug delivery was studied.
Methods:
Stearic acid–grafted chitosan (CS-SA) was synthesized by hydrophobic
modification of chitosan with stearic acid. The physicochemical
characteristics of CS-SA micelles were investigated. bEnd.3 cells were
chosen as model cells to evaluate the internalization ability and
cytotoxicity of CS-SA micelles in vitro. Doxorubicin (DOX), as a model
drug, was physically encapsulated in CS-SA micelles. The in vivo
brain-targeting ability of CS-SA micelles was qualitatively and
quantitatively studied by in vivo imaging and high-performance liquid
chromatography analysis, respectively. The therapeutic effect of
DOX-loaded micelles in vitro was performed on glioma C6 cells.
Results:
The critical micelle concentration of CS-SA micelles with 26.9% ± 1.08%
amino substitute degree was 65 µg/mL. The diameter and surface
potential of synthesized CS-SA micelles in aqueous solution was 22 ±
0.98 nm and 36.4 ± 0.71 mV, respectively. CS-SA micelles presented
excellent cellular uptake ability on bEnd.3 cells, the IC50
of which was 237.6 ± 6.61 µg/mL. DOX-loaded micelles exhibited slow
drug-release behavior, with a cumulative release up to 72% within 48
hours in vitro. The cytotoxicity of DOX-loaded CS-SA micelles against C6
was 2.664 ± 0.036 µg/mL, compared with 0.181 ± 0.066 µg/mL of DOX •
HCl. In vivo imaging results indicated that CS-SA was able to transport
rapidly across the blood–brain barrier and into the brain. A maximum DOX
distribution in brain of 1.01%/g was observed 15 minutes after
administration and maintained above 0.45%/g within 1 hour. Meanwhile,
free DOX • HCl was not detected in brain. In other major tissues,
DOX-loaded micelles were mainly distributed into lung, liver, and
spleen, with a reduction of DOX accumulation in heart.
Conclusion: The CS-SA micelles were able to be used as a promising carrier for a brain-targeting drug delivery system.
Keywords: chitosan, stearic acid, micelle, blood–brain barrier, brain targeting, in vivo imaging
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,972 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment